Reviewed by: Rob Miller
4 OUT OF 5
Walk in to a consultation with just about any gastroenterologist on the face of the earth and you will hear about “good” bacteria in your intestinal tract, known as “probiotics."Q
These beneficial bacteria are present in the human body in such numbers that they are more populous in the human body than cells native to human biology on an exponential level.
There are countless different strains and species, each with subtle variations on their overall effect on human health and disease processes.
We have previously covered the intricate details of what these beneficial bacteria are and just precisely what roles they play in our bodies in our educational piece on probiotics.
Here, you will find invaluable information about probiotics and prebiotics, coupled with some of the buzzwords and gimmicks that the supplement industry uses to drive sales – some of which are true, while others are red flags at best and outright misleading or even false at worst.
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Now, there are hundreds – if not thousands – of different brand-name and even generic probiotic formulations.
These can range from isolated strains, such as the popular and well-known acidophilus supplements that you can find in any vitamin aisle in any supermarket in the country, to the “top-shelf” advertised products that claim to combine the health benefits of probiotics with other ingredients contained.
These combination products generally claim to be proprietary formulas and are generally priced much higher than their standalone competitors.
Bio X4 from Nucific, is one such combination formula that purports to be a probiotic-based product that not only has the proven health benefits of multi-strain probiotic supplementation but also combines ingredients from three other supplement families in order to act as a complete weight-management solution.
The question is, will the asserted claims of Bio X4 highly-priced ($139 for a 30-day supply) formula be worth their weight in gold?
Or will this product be another formula full of so many false claims that it is just another example of the embodiment of the unbridled greed that sometimes saturates the largely unregulated supplements industry?
Probiotics Facts and Myths
The science and research behind probiotics and their symbiotic role with the biology of humankind has accelerated at a tremendous pace, specifically since the late 1990s, such that as clinical trials of different strains of probiotics increasingly demonstrated positive results, this core concept of immunology rewrote itself into the treatment of many different conditions, ranging from irritable bowel syndrome to depression.
In fact, recent studies have shown that over 80% of the human immune system actually originates from the intestinal flora, which is populated with the traditional “bad” bacteria that we think of when we think of “antibiotics,” as well as these beneficial probiotics, with the balance of these different organisms being tantamount to good health. These many trillions of living cellular entities coexist in a delicate balance that has implications system-wide inside the human body.
It only makes sense, then, that it is very important to maintain a healthy balance of probiotic organisms in one’s intestinal flora if one wishes to reap the benefits that these bacteria have to offer.
Probiotics are classified by the FDA as dietary supplements, which means they are not subject to the intense scrutiny and regulations as pharmaceutical agents.
While this detail provides the supplement industry with the ability to spark innovation without fear of governmental interference, it also means that supplements can also be associated with having a negative image because of the countless false claims that are make on a regular basis without penalty.
So, if you are a supplement user, you already know that the market is full of these products, and you should already know that an informed supplement shopper is the best supplement shopper, and this is especially true of purported “special formulation” products like Bio X4.
What is Bio X4?
As mentioned above, the manufacturer advertises this supplement as a “4-in-1” weight management solution.
This is due to the “revolutionary new” formula contained within the supplement, that will provide the user with digestive support, appetite suppression, and weight management, due to the unique combination of four different ingredients, the base of which is a probiotic blend.
When I was originally doing my research for Bio X4, I came across a video that is ultimately a pitch for the supplement.
It’s narrated by a Dr. Amy Lee, a Bariatric Physician who specializes in nutrition, wellness, and weight management and is the founder of the Integrative Wellness Center located in Los Angeles, CA.
What was a bit strange, though, is that when I went to the Integrative Wellness Center About page, I don’t see any mention of Dr. Amy Lee.
Now, Nucific does a pretty good job of controlling the distribution rights of this supplement, as it seems there are only two ways to order; direct from their website (www.Nucific.com/Bio-X4) and on Amazon.
However, I was recently contacted by a representative from Nucific Bio X4, and she told me that they do NOT authorize any resellers on Amazon or eBay.
When people buy from these resellers, I was told they cannot guarantee the authenticity of the product they are buying, or whether the product is properly stored and shipped.
Additionally, because you’re ordering from Amazon, these 3rd party resellers do not exercise a 90-day money back guarantee, offer a plethora of free email content, or offer customer service.
Purchasing from their website allows one to take advantage of a “special introductory price” of $99 for the first month.You can also order in quantities of up to a 180-day supply for just under $500. They do offer a 90-day risk-free trial period, billed as a money-back guarantee, which is always a good thing when dealing with any new supplement.
Bio X4 Label and Packaging – Red Flags
This product is advertised with some very standard tactics used to inflate the claims of effectiveness for many different supplement products.
For example, as indicated on the Bio X4 label, the manufacturer has combined its core blend of different probiotics with a “digestive enzyme compound,” green tea extract (EGCG), and Caralluma Fimbriata.
The serving size is one capsule three times per day, and the 90-capsule bottle is equivalent to a one-month supply.
Now, upon looking at this label and reading the product information, there are some immediate red flags that pop right out due.
The first one that just screams out is the claim that, by taking 3 capsules a day in addition to staying away from carbs and sweets as well as beginning an exercise regimen, that you will begin to experience results in 1-2 months.
You’re probably thinking that this claim doesn’t seem to be too overzealous, so why does it send off warning shots?
Well, it’s the kind of claim that really means nothing at all, because a person who cuts out unnecessary carbohydrates and sweets from his/her diet and who concurrently begins a regular exercise regimen should start to see results in 1-2 months regardless.
So, unless this 1-2 month weight loss amount was so absolutely remarkable (it’s not) that completely delineated users of Bio X4 from the rest of a controlled population trying to lose weight without it, the claim itself is absolutely meaningless.
How Does Bio X4 Differentiate Itself?
So, if this product’s main claim regarding weight loss falls apart so quickly, what is it about Bio X4 that makes it stand out from the competition?
Is there really such a significant advantage to the “revolutionary new” formulation that the massive price tag of $139.95 for a 30-day supply is warranted?
Well, let’s explore each ingredient contained therein to determine if there really is a solid benefit to this particular brand or if the $18.91 competitor will bestow the same benefits upon the user.
We will also take a look at some of the feedback from real consumers who have used this product.
Adverse Effects Possibilities and Allergy Warning
It goes without saying that trying any new dietary supplement should not be undertaken unless the user has scoured the label for any obvious signs of ingredients he/she may be allergic to.
Then, once a person has made sure that none of the ingredients are known personal allergens, the next step in determining whether the product is safe is to investigate the individual components against any reports of adverse effects by people who have used the supplement.
With regards to Bio X4, the individual components as listed should not cause many serious side effects, and any minor irritations that occur will disappear with time.
This includes the possibility of excess bloating, upset stomach, diarrhea, and other mild gastrointestinal symptoms that can occur when a person begins using probiotics.
These symptoms will go away with time if they occur at all.
The only other possible adverse effect that could occur in any real sizable population would be the inherent caffeine content that could be associated with green tea extract, and even then, such effects would only occur in those who are caffeine-sensitive individuals.
So, the real concern with Bio X4 is not going to come with any risk attached to its ingredients, but whether the ingredients as combined and dosed will have any noticeable effect at all.
Let’s look at each of these ingredients.
The label on Bio X4 shows that the probiotics a combination of Lactobacillus and Bifidobacterium species (the most well-known of probiotic species), for a total of five different strain at a total of 4 billion CFUs (that is, colony-forming units, the standard of measurement regarding all bacteria – the more CFUs, the more chance that the beneficial bacteria will populate the intestinal tract) per capsule.
Now, you may think, “Wow! Four billion organisms! That’s a lot!
However, a quick search for “probiotics” on a major shopping site will reveal a competitor to Bio X4 mentioned above that offers a total of 34.7 billion CFUs plus a total of 14 strains of different Lactobacillus and Bifidobacterium organisms per capsule.
The most unsettling thing about this comparison is not the difference in strains in the competition, but the price of this superior product, which comes in at a whopping 10% of the cost of Bio X4.
With that said, while the strains of probiotic bacteria in Bio X4 may provide the user with some digestive benefits, including reduction of long-term bloating and gas, the product simply does not stack up to its much cheaper, far-superior competition with regards to its probiotic content in terms of both the amount per serving (34.7 billion CFUs in the competition versus 4 billion in Bio X4) and the variety and diversity of different strains (11 in the competition versus 5 in Bio X4).
But wait, what about the “revolutionary new compound”?
Could it be possible that the combination of the probiotics in Bio X4 with the other ingredients could really synergize in such a manner that the benefits justify the hefty price tag?
Is there some sort of magical property of Bio X4 that makes it more beneficial to overall health than making your own 4-part regimen out of standalone supplements?
Let’s explore that as well.
Digestive Enzyme Blend:
According to Bio X4’s label, each capsule contains 88 mg of a blend of “digestive enzymes” containing Amylase (from Aspergilus Oryzae), Bromelain, and Lipase (from Rhizopus Oryzae).
Coincidentally, amylase and lipase are 2 of the major enzymes responsible for the digestion and absorption of nutrition from food.
So, what health benefits might these enzymes contribute to?
Amylase “catalyses the hydrolysis of starch into sugars."Q Being that this digestive enzyme deals with sugar digestion, it would only make sense that amylase supplementation may be of some benefit in diabetes prevention.
Furthermore, it is also suspected that this enzyme may play a role in improving digestion, preventing some types of cancer, and boosting energy levels.
Bromelain is a mixture of multiple digestive enzymes that aid in the digestion of proteins.
This mix of enzymes can be found in pineapples and has been shown to be effective at reducing swelling and inflammation, especially with regards to sprains, postoperative pain, and tendinitis.
Lipase “catalyses the hydrolysis of lipids."Q A high level of this enzyme is generally a marker of pancreatitis, and as such, there is some preliminary evidence that supplementation with lipase may be of benefit for those suffering with pancreatic disorders, and may further reduce bloating, indigestion, and excess gas.
So how does the enzyme blend of Bio X4 stack up when compared to similar standalone enzyme products?
Well, while there are definitely some promising potential benefits to supplementation with these vital digestive enzymes, the problem with Bio X4 once again comes down to the astronomical price tag associated with this supplement.
It is just plain insane to justify spending $139.99 (or even the first-time buyer discounted price directly from the manufacturer of $99.00 for a 30-day supply) for a supplement such as Bio X4, especially when you can simply combine a superior digestive enzyme supplement, such as Nature’s Way Digestion with Enzymes, which combines beneficial herbs with the same enzyme blend at a much more significant dose than what is included in Bio X4, at a much more affordable price of $10.88.
Weight Management Blend (Green Tea Extract – 100 mg)
Now, there does seem to be some promise in this area when it comes to the major constituent of green tea, a compound known as EGCG, of which Bio X4 contains 100 mg per serving.
Studies have also shown some promise with regards to the treatment of sepsis with EGCG in animal studies, but as of 2015, these claims have not been proven in human disease processes.
However, once again, the key point here is the price comparison.
While the “all-in-one” approach seen in Bio X4 may be a bit more convenient than taking several different supplements, this perceived convenience simply cannot justify such a steep price tag, especially when there are green tea supplements, such as
scid=3763&cmp=gpl-_-herbalsupplements-_-012227&gclid=CjwKEAiAmo_CBRC9qbGQssjqi28SJABYTgZx_KcRd-AXOIfBD-gTNC5i-G7eA0xyz891LGa9Cd_1RhoCTLjw_wcB&noredirect=true&ssl=1">this one from Jarrow, that contain 5x the amount of EGCG as Bio X4, and can be purchased for the much more sensible price of $6.99 for a quantity of 100 capsules.
Craving Control Blend (consisting of 166 mg of Caralluma Fimbriata extract)
Caralluma is an herb that Indian populations have historically chewed as a method of controlling hunger during long hunting expeditions.
Bio X4 contains an extract of this herb as a “craving controller."Q
Unfortunately, while there may be such anecdotal evidence supporting this, there is currently insufficient evidence to show any scientific validity to this claim.
While this does not mean that the claims are untrue, it really boils down to an individual experience as to whether this ingredient will be of any beneficial use in controlling hunger and cravings.
lpid=82&chn=ps&ul_noapp=true">This particular supplement is generally representative of what you will find out there in terms of single-ingredient Caralluma supplements, and at $5.95 for a 30-day supply (with a serving size that is 9 times the amount found in Bio X4); the frugal supplement user will be incredibly happy going with one of these instead of Bio X4.
Bio X4 Reviews – What Are They Saying?
Reviews for Bio X4 on a wide variety of sites are mixed, with the vast majority being positive.
Most of the positive reviews came from people who gave the formula positive reviews based on some very subtle positive gastrointestinal benefits they experienced.
For example, the website Highya has a total of 297 reviews, with an average rating of 4.5 out of 5 stars.
Reading through these reviews, you’ll see that many users report benefits such as:
- Improved food digestion
- Reduced gas and bloating
- Increased appetite suppression
- Increased libido
- Enhanced vitality and energy
Many of these are very careful to warn others not to get up hopes that this is some sort of miracle cure. , which is good advice.
On the flip side, there are plenty of negative reviews on Amazon, with users warning other people not to waste their time.
As mentioned earlier in this review, Amazon resellers selling Bio X4 do not represent Nucific.
Therefore, it’s unknown how credible the reviews on Amazon are when they come from 3rd party resellers.
Another negative comment that seems to be a steady complaint about the product is that there is very little to no effect on appetite whatsoever.
Some of the other negative comments seem to stem from their up-selling process.
One user reported being charged for close to 7 bottles when he only wanted 1.
However, it’s important to note that this same user contacted the customer service department at Nucific and promptly received a refund.
This gives us proof that the company indeed does adhere to their 90 day money back guarantee.
My Personal Results
I ended up taking Bio X4 and after a few days started to feel a bit strange.
I’ve never actually taken a probiotic supplement before, but something in Bio X4 was giving me terrible gas, indigestion, and an upset stomach.
I stopped taking it at around day 4, so unfortunately I can’t tell you what sort of long term effects you may get from it.
Of course I can’t be 100% certain that Bio X4 was the culprit here, but I wasn’t about to continue taking it based on the effects I was getting.
I’m thinking about having my wife try it out so we can get an accurate gauge as to it’s effectiveness, or if I get brave maybe I’ll give it another shot down the road.
The Bottom Line on Bio X4
Nucific Bio X4 is a combination product that mixes beneficial probiotic strains with three other supplements for what is supposed to be a 4-way approach to digestive health and weight management.
Based solely on the reviews, it looks like a winner.
The vast majority of people that take it seem to get great results, while the complaints are kept to a minimum due to their positive customer service experiences and 90-day money back guarantee.
While it is convenience – even preferable – to reduce the number of pills that one must swallow to obtain all of these different compounds, it is very clear that the manufacturer has slapped on a very inflated price tag on a product that may have some beneficial properties.
While the benefits of the probiotic strains from the Lactobacillus and Bifidobacterium families contained in Bio X4 may be real, the other ingredients suffer from the plague of “insufficient clinical data” that many other supplements also have issues with.
Furthermore, by simply procuring separate sources for each of the four ingredient classes that are present in Bio X4, the price-conscious supplement user has the possibility of the experiencing extra benefits that the larger doses present in standalone products may contribute to.
Even with the special introductory price of $99.00 for the first month’s bottle (and $139.99 per 30-day supply afterwards), one would be remiss not to consider the possibility of taking each ingredient separately.
When purchased separately, one can obtain a far-superior probiotic blend for a $18.91, a far-superior digestive enzyme blend for $10.88, an EGCG supplement with five-fold strength for $6.99, and a Caralluma supplement with a whopping 900% stronger dose for $5.99.This means that you can end up with a much more powerful supplementation with the separate ingredients for a total of $42.77, which equates to less than 45% of the special introductory price of Bio X4 and a miniscule 30% of the price of the retail price of $139.00.
As such, unless you find it completely and absolutely impossible to take 4 pills instead of one (the only real positive point for Bio X4), you would be much better off, in terms of both supplement dose strength as well as price, by simply ordering separate supplements for each of the four ingredient categories found in the “revolutionary new” formulation that is Nucific’s Bio X4.
The bottom line is, while there may be some minor overall health benefit and some significant gastrointestinal benefits from taking Bio X4, the astronomical price of this supplement coupled with the less-than-stellar dosage amounts of probiotics, enzymes, EGCG, and Caralluma contained therein certainly seem to make this product a cautionary tale of what happens when supplement manufacturers overstate claims in order to simply make as much money as possible from those who know no better.
Unfortunately, for us Bio X4’s price is too high and its dosage is too low.
So, do yourself a favor and save close to $1000 a year – or the equivalent of approximately six-months’ worth of electric bill payments – by simply buying each of these supplements in their standalone formulations.In this case, it is very prudent not to be fooled by the aesthetically pleasing, sleek-looking package and well-placed, paid testimonials that house the supplement that is Bio X4. Your wallet will definitely thank you for doing your due diligence instead of just clicking “buy now” on the product with the prettiest package.
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User Questions and Answers
User Questions and Answers
If I were to buy each supplement separately, would I still take them each 3x a day before each meal? -Sarah
If you were to purchase the major ingredients and use them separately, follow each of their label instructions.- Rob
4 out of 4 people found this question helpful.
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