Bio X4 Warnings

Author: Dr. Brian Straub, Pharm.D.
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Here are some frequently asked medical questions we get for Bio X4.

Click Here for a full list of potential drug interactions.

Can I take BioX4 if I have high blood pressure?

  • This supplement does not appear to have any contraindications for those with high blood pressure.

Can I take BioX4 if I have LOW blood pressure?

  • This supplement does not appear to have any contraindications for those with low blood pressure.

Can I take BioX4 if I have diabetes?

  • Some of the ingredients may lower blood sugar and alter the effects of insulin.

    When adding a new supplement that may lower blood sugar, it is best to monitor your blood sugar daily for the first week.

    If you experience hypoglycemia, stop the supplement and speak with your doctor about possibly altering your regimen.

Are allergic reactions possible with BioX4?

  • As with all supplements and medications there is the possibility of allergic reactions.

    Do not take if you are allergic to pork protein, pineapple, latex, wheat, celery, papain, carrot, fennel, cypress pollen or grass pollen.

Can I take BioX4 with alcohol?

  • Although it is always best to limit alcohol consumption when taking supplements, there appear to be no adverse effects when taking with alcohol.

Can I take BioX4 with Viagra / Cialis?

  • There appear to be no interactions between this supplement and this class of medications.

Can I take if I am taking anti-depressants?                               

  • There are no known interactions between this supplement and anti-depressant medications.

Can I take Bio X4 if I have a bleeding disorder?

  • It is best to avoid this supplement if you are taking blood thinners.

    There is that possibility that an ingredients in this product may decrease your body’s clotting ability (thin your blood).

    If you do choose to use this supplement, monitor for signs and symptoms in increased bleeding including bruising and bleeding gums.

Can I take Bio X4 with caffeine or other stimulants?

  • The green tea extract used most likely has a low level of caffeine present, but it is unlisted amount.

    Many of the potential stimulant adverse effects are related to interactions with caffeine.

    This will depend on your body’s sensitivity to caffeine.

Can I take Bio X4 if I am pregnant, planning to become pregnant or breastfeeding?

  • There is not enough reliable evidence to support if this supplement is safe or unsafe during pregnancy or breastfeeding.

Are there any others medical reasons why I shouldn’t take Bio X4?

Do not take this medication if you have:

  • Weakened Immune System (There is some concern that live bacteria from probiotic supplements might grow too well in people whose immune systems are weakened.

    This includes people with HIV/AIDS or people who have taken medicines to prevent rejection of a transplanted organ.

    Lactobacillus has caused disease (rarely) in people with weakened immune systems.

    To be on the safe side, if you have a weakened immune system, talk with your healthcare provider before taking lactobacillus.
  • Short bowel syndrome
  • Ulcerative colitis
  • Damaged heart valves
  • Intestinal Blockage
  • Pancreatitis
  • Anemia
  • Glaucoma
  • IBS
  • Liver Disease
  • Osteoporosis
  • Heart Conditions
  • Behavioral or psychiatric conditions such as depression, anxiety, or schizophrenia

You should stop taking this supplement within two weeks of any surgery.

Possible Drug Interactions

Major (depending on caffeine sensitivity):

  • Amphetamines
  • Ephedrine
  • Cocaine


  • Mental Health
    • MAOI’s
      • phenelzine (Nardil)
      • tranylcypromine (Parnate)
    • Fluvoxamine (Luvox)
    • Lithium
  • Auto-Immune Medications (immunosuppressants for transplant, rheumatoid arthritis, psoriasis, etc.)
    • azathioprine (Imuran)
    • cyclosporine (Neoral, Sandimmune)
    • mycophenolate (CellCept)
    • tacrolimus (Prograf)
    • sirolimus (Rapamune)
    • prednisone (Deltasone, Orasone)
    • corticosteroids (prednisone, etc)
    • and others
  • Blood Thinners
    • Aspirin
    • clopidogrel (Plavix)
    • diclofenac (Voltaren, Cataflam, others)
    • ibuprofen (Advil, Motrin, others)
    • naproxen (Anaprox, Naprosyn, others)
    • dalteparin (Fragmin)
    • enoxaparin (Lovenox)
    • heparin
    • warfarin (Coumadin)
    • and others.
  • Birth Control
  • Estrogens
  • Amphetamines
    • Adderall
  • Stimulants
    • diethylpropion (Tenuate)
    • epinephrine
    • phentermine (Ionamin)
    • pseudoephedrine (Sudafed)
    • and many others.
  • Antibiotics (ALL, below are a just a few different classes)
    • Penicillins
      • amoxicillin
    • Quinolones
      • ciprofloxacin (Cipro)
      • enoxacin (Penetrex)
      • norfloxacin (Chibroxin, Noroxin)
      • sparfloxacin (Zagam)
      • trovafloxacin (Trovan)
      • grepafloxacin (Raxar)
    • Tetracyclines
      • demeclocycline (Declomycin)
      • minocycline (Minocin)
      • tetracycline (Achromycin)
    • Medications Metabolized by the Liver
      • Hepatotoxic Drugs
        • acetaminophen (Tylenol and others)
        • amiodarone (Cordarone)
        • carbamazepine (Tegretol)isoniazid (INH)
        • methotrexate (Rheumatrex)
        • methyldopa (Aldomet)
        • fluconazole (Diflucan)
        • itraconazole (Sporanox)
        • erythromycin (Erythrocin, Ilosone, others)
        • phenytoin (Dilantin)
        • lovastatin (Mevacor)
        • pravastatin (Pravachol)
        • simvastatin (Zocor)
      • Other
        • Adenosine
        • clozapine (Clozaril)
        • dipyridamole (Persantine)
        • disulfiram (Antabuse)
        • nicotine



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Author: Dr. Brian Straub, Pharm.D.

Brian Straub is a medical science liaison and licensed clinical pharmacist. He graduated from the University of Pittsburgh School of Pharmacy in 2011, and is also a registered yoga instructor.