Lumiday Warnings (UPDATED 2018) – Updated By A Licensed Pharmacist

Author: Dr. Brian Straub, Pharm.D.
Home » Stress Relief » Lumiday Warnings (UPDATED 2018) – Updated By A Licensed Pharmacist

Lumiday Warnings – Drug and Medical Condition Interactions

Lumiday is a popular mood enhancing supplement that we’ve actually tested in the past.

There are numerous potential drug interactions, those of which are listed below.

Click Here for a full list of potential drug interactions.

Here are some popular health related questions that we get:

Can I take Lumiday if I have high blood pressure?

  • Some of the ingredients in Lumiday may cause low blood pressure.

    Use caution if you are currently taking any medications to lower your blood pressure.

Can I take Lumiday if I have LOW blood pressure?

  • May cause low blood pressure, used caution if you have low blood pressure.

Can I take Lumiday if I have diabetes?

  • Some of the ingredients may alter blood sugar and alter the effects of insulin.

    When adding a new supplement that may alter blood sugar, it is best to monitor your blood sugar daily for the first week.

    If you experience hypoglycemia, stop the supplement and speak with your doctor about possibly altering your regimen.

Are allergic reactions possible with Lumiday?

  • Do not use if you have an allergy or sensitivity to cobalt or cobalamin. Niacin, found in this supplement, might worsen allergies by causing histamine, the chemical responsible for allergic symptoms, to be released.

Can I take Lumiday with alcohol?

  • It is best to avoid alcohol when taking any supplement, especially those that are used to improve mood as alcohol is a depressant.

    Additionally, some of the ingredients in this supplement may interact with alcohol.

Can I take if I am taking anti-depressants?                               

  • A main ingredient in this supplement increases serotonin.

    Most anti-depressant medications also increase serotonin.

    If serotonin levels are increased too much, this could lead to serious side effects including heart problems, shivering, and anxiety.

    Do not take if taking anti-depressant medications.

Can I take if I have a bleeding disorder?

  • It is best to avoid this supplement if you have a bleeding disorder or taking blood thinners.

    A few of the ingredients in this product may alter your body’s clotting ability.

    If you do choose to use this supplement, monitor for signs and symptoms in increased bleeding including bruising and bleeding gums.

Can I take with caffeine or other stimulants?

  • Stimulants have the potential of worsening symptoms of anxiety and depression.

    It is best to avoid caffeine.

Can I take Lumiday if I am pregnant, planning to become pregnant or breastfeeding?

  • Do not take this supplement if you are pregnant, breast-feeding or trying to become pregnant.

    Some of these ingredients are listed as probably unsafe in pregnancy, and other ingredients have could decrease your chance of getting pregnant.

Can I take Lumiday at night?

  • The Rhodiola in the supplement may increase alertness and may make it more difficult to sleep.

    Everyone reacts differently, as this ingredient and others in this supplement may provide a sense of calming that may aid sleep.

Can Lumiday make you tired?  Would any of these ingredients cause fatigue?

  • None of the ingredients in this supplement stand out as making you tired.

    As with any supplement that can alter brain chemistry, everyone can react differently.

    L-theanine can promote relaxation but is balanced out by the Rhodiola which can give you energy.

Does Lumiday cause weight gain?

  • There do not appear to be any direct correlations between this medication and weight gain.

    It is hypothesized that 5-HTP may actually aid in weight-loss.

    That being said, this supplement helps to increase serotonin in the brain, and in some instances, may increase appetite.

Are there any others medical reasons why I shouldn’t take this supplement?

Do not take this medication if you have:

  • Stomach Ulcers
  • “Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions
  • Thyroid Disorders
  • Alzheimer’s
  • AHDH
  • Bipolar Disorder
  • Depression (may bring on mania)
  • Trying to conceive a child
  • Schizophrenia
  • Sunlight exposure
  • Hemophilia
  • Ulcerative Colitis
  • Leber’s disease, a hereditary eye disease
  • Abnormal red blood cells (megaloblastic anemia)
  • High numbers of red blood cells (polycythemia vera)
  • Anemia Caused by B12 Deficiency
  • Seizure Disorder
  • Cancer
  • Procedures to widen narrowed arteries (angioplasty)
  • Heart disease/unstable angina
  • Crohn’s disease
  • Gallbladder disease
  • Gout
  • Kidney disease
  • Liver disease
  • Stomach or intestinal ulcers
    Fatty deposits around tendons (tendon xanthomas)
  • Thyroid disorders
  • Parkinson’s

You should stop taking this supplement within two weeks of any surgery.

Possible Drug Interactions


  • Mental Health
    • Antidepressants
      • fluoxetine (Prozac)
      • paroxetine (Paxil)
      • sertraline (Zoloft)
      • amitriptyline (Elavil)
      • clomipramine (Anafranil)
      • imipramine (Tofranil)
      • sertraline (Zoloft)
      • escitalopram (Lexapro)
      • and others
    • Benzodiazepines
      • Alprazolam
      • Lorazepam
      • Diazepam
    • MAOI’s
      • phenalgine (Nardil)
      • tranylcypromine (Parnate)
    • Other Antidepressants
      • fluoxetine (Prozac)
      • paroxetine (Paxil)
      • sertraline (Zoloft)
      • amitriptyline (Elavil)
      • clomipramine (Anafranil)
      • imipramine (Tofranil)
      • and others.
    • HIV/AIDS
      • (Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)
        • nevirapine (Viramune)
        • delavirdine (Rescriptor)
        • efavirenz (Sustiva)
      • Protease Inhibitors
        • amprenavir (Agenerase)
        • nelfinavir (Viracept)
        • ritonavir (Norvir)
        • saquinavir (Fortovase, Invirase)
      • Medications metabolized by the liver:
        • Liver Enzyme 3A4
          • lovastatin (Mevacor)
          • clarithromycin (Biaxin)
          • cyclosporine (Neoral, Sandimmune)
          • diltiazem (Cardizem)
          • estrogens
          • indinavir (Crixivan)
          • triazolam (Halcion), and many others.
        • P-glycoprotein Substrates
          • diltiazem (Cardizem)
          • verapamil (Calan, Isoptin, Verelan)
          • digoxin (Lanoxin)
          • cyclosporine (Neoral, Sandimmune)
          • saquinavir (Invirase)
          • amprenavir (Agenerase)
          • nelfinavir (Viracept)
          • loperamide (Imodium)
          • quinidine,
          • paclitaxel (Taxol)
          • vincristine, etoposide (VP16, VePesid)
          • cimetidine (Tagamet)
          • ranitidine (Zantac)
          • fexofenadine (Allegra)
          • ketoconazole (Nizoral)
          • itraconazole (Sporanox)
        • Photosensitizing Drugs
          • amitriptyline (Elavil)
          • Ciprofloxacin (Cipro)
          • norfloxacin (Noroxin)
          • lomefloxacin (Maxaquin)
          • ofloxacin (Floxin)
          • levofloxacin (Levaquin)
          • sparfloxacin (Zagam)
          • gatifloxacin (Tequin)
          • moxifloxacin (Avelox)
          • trimethoprim/sulfamethoxazole (Septra)
          • tetracycline
          • methoxsalen (8-methoxypsoralen, 8-MOP, Oxsoralen)
          • Trioxsalen (Trisoralen)
        • Birth Control Pills
          • estradiol and levonorgestrel (Triphasil)
          • ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7)
          • and others
        • Pain Meds (Narcotics)
          • meperidine (Demerol)
          • hydrocodone
          • morphine
          • OxyContin
          • and many others
        • Auto-Immune Medications (immunosuppressants for transplant, rheumatoid arthritis, psoriasis, etc.)
          • azathioprine (Imuran)
          • cyclosporine (Neoral, Sandimmune)
          • mycophenolate (CellCept)
          • tacrolimus (Prograf)
          • sirolimus (Rapamune)
          • prednisone (Deltasone, Orasone)
          • corticosteroids (prednisone, etc)
          • and others
        • Blood Thinners
          • Aspirin
          • clopidogrel (Plavix)
          • diclofenac (Voltaren, Cataflam, others)
          • ibuprofen (Advil, Motrin, others)
          • naproxen (Anaprox, Naprosyn, others)
          • dalteparin (Fragmin)
          • enoxaparin (Lovenox)
          • heparin
          • warfarin (Coumadin)
          • and others.
        • Other
          • Digoxin
          • Fenfluramine (Pondimin)
          • Imatinib (Gleevec)
          • Irinotecan (Camptosar)
          • Meperidine (Demerol)
          • Sedative medications (Barbiturates)
          • Nefazodone (Serzone)
          • Pentazocine (Talwin)
          • phenobarbital (Luminal)
          • Phenprocoumon
          • Phenytoin (Dilantin)
          • Reserpine
          • Tramadol
          • Aminolevulinic acid
          • Amitriptyline (Elavil)
          • Chloramphenicol

Moderate Interactions:

  • Statins
    • rosuvastatin (Crestor)
    • atorvastatin (Lipitor)
    • lovastatin (Mevacor)
    • pravastatin (Pravachol)
    • simvastatin (Zocor)
  • Bile Acid Sequesterants
    • cholestyramine (Questran)
    • colestipol (Colestid)
  • Antidiabetic medications
    • glimepiride (Amaryl)
    • glyburide (DiaBeta, Glynase PresTab, Micronase)
    • insulin
    • pioglitazone (Actos)
    • rosiglitazone (Avandia)
    • chlorpropamide (Diabinese)
    • glipizide (Glucotrol)
    • tolbutamide (Orinase)
    • and others
  • Triptans
    • frovatriptan (Frova)
    • naratriptan (Amerge)
    • rizatriptan (Maxalt)
    • sumatriptan (Imitrex)
    • zolmitriptan (Zomig)
  • Medications metabolized by the liver:
    • Liver Enzyme 2C9
      • amitriptyline (Elavil)
      • diazepam (Valium),
      • zileuton (Zyflo)
      • celecoxib (Celebrex)
      • diclofenac (Voltaren)
      • fluvastatin (Lescol)
      • glipizide (Glucotrol)
      • ibuprofen (Advil, Motrin)
      • irbesartan (Avapro)
      • losartan (Cozaar)
      • phenytoin (Dilantin)
      • piroxicam (Feldene)
      • tamoxifen (Nolvadex)
      • tolbutamide (Tolinase)
      • torsemide (Demadex)
      • warfarin (Coumadin), and others.
    • Liver Enzyme 1A2
      • amitriptyline (Elavil)
      • haloperidol (Haldol)
      • ondansetron (Zofran)
      • propranolol (Inderal)
      • theophylline (Theo-Dur, others)
      • verapamil (Calan, Isoptin, others)
      • and others
    • Other
      • Aluminum
      • Calcipotriene (Dovonex)
      • Digoxin (Lanoxin)
      • Diltiazem (Cardizem, Dilacor, Tiazac)
      • Carbidopa (Lodosyn
      • Dextromethorphan (Robitussin DM)
      • Meperidine (Demerol)
      • Pentazocine (Talwin)
      • Tramadol (Ultram)
      • Fexofenadine (Allegra)
      • Procainamide
      • Simvastatin
      • Fosphenytoin (Cerebyx)
      • Methotrexate (MTX, Rheumatrex)
      • Allopurinol (Zyloprim)
      • Carbamazepine (Tegretol)
      • Clonidine (Catapres)
      • Sulfinpyrazone (Anturane)
      • Probenecid
      • Primidone (Mysoline)
      • Pyrimethamine (Daraprim)



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Author: Dr. Brian Straub, Pharm.D.

Brian Straub is a medical science liaison and licensed clinical pharmacist. He graduated from the University of Pittsburgh School of Pharmacy in 2011, and is also a registered yoga instructor.