Zyrexin Warnings

By: Rob Miller

Zyrexin Prescription And Medical Condition Interactions

Zyrexin is a product we’ve personally tested.

Our pharmacist reviewed the formula, and has written up the potential drug interactions and medical condition interactions that may be possible with Zyrexin.

Click Here for a full list of potential drug interactions.

Warning: Yohimbe (found in this supplement) and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.

Taking high doses can also cause other severe problems, including difficulty breathing, paralysis, very low blood pressure, heart problems, and death.

After taking a one-day dose of yohimbine, one person reported an allergic reaction involving fever; chills; listlessness; itchy, scaly skin; progressive kidney failure; and symptoms that looked like the auto-immune disease called lupus.

Can I take Zyrexin if I have high blood pressure?

  • Ingredients in this supplement may cause a drop in blood pressure, use caution if you are already taking medications to lower your blood pressure.

Can I take Zyrexin if I have LOW blood pressure?

  • Ingredients in this supplement may cause a drop in blood pressure, use caution.

Can I take Zyrexin if I have diabetes?

  • Some of the ingredients may lower blood sugar and alter the effects of insulin.

    When adding a new supplement that may lower blood sugar, it is best to monitor your blood sugar daily for the first week.

    If you experience hypoglycemia, stop the supplement and speak with your doctor about possibly altering your regimen.

Are allergic reactions possible with Zyrexin?

  • L-arginine, found in this supplement, can cause an allergic response or make swelling in the airways worse.

    If you are prone to allergies or asthma and decide to take L-arginine, use it with caution.

Can I take Zyrexin with alcohol?

  • While it is best to avoid alcohol while taking supplements, there is no evidence that this supplement interacts with alcohol.

Can I take Zyrexin with Viagra / Cialis?

  • Ingredients in this supplement may lower blood pressure.

    Taking in combination with Viagra or Cialis may lower your blood pressure to an unsafe level.

    Use caution.

Can I take if I am taking anti-depressants?                               

  • It is best to avoid this supplement if you are taking any anti-depressant medications or suffer from any mental illness.

Can I take Zyrexin if I have a bleeding disorder?

  • It is best to avoid this supplement if you are taking blood thinners.

    If you do choose to use this supplement, monitor for signs and symptoms in increased bleeding including bruising and bleeding gums.

Can I take with caffeine or other stimulants?

  • It is best to avoid stimulants while taking this supplement.

Are there any others medical reasons why I shouldn’t take this supplement?

Do not take this medication if you have:

  • Bleeding Conditions
  • Schizophrenia
  • Prostate Problems
  • PTSD
  • Liver Disease
  • Kidney Disease
  • Chest Pain/Heart Disease
  • Anxiety
  • Depression
  • Diabetes
  • Deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD)
  • Seizures
  • Diseases of the heart and blood vessels
  • Skin cancer
  • Peptic Ulcer Disease
  • Cirrhosis or liver disease
  • Guanidinoacetate methyltransferase deficiency
  • Herpes
  • Recent Heart Attack

You should stop taking this supplement within two weeks of any surgery.

Possible Drug Interactions


  • Mental Health
    • MAOI’s
      • phenelzine (Nardil)
      • tranylcypromine (Parnate)
    • Blood Thinners
      • Aspirin
      • clopidogrel (Plavix)
      • diclofenac (Voltaren, Cataflam, others)
      • ibuprofen (Advil, Motrin, others)
      • naproxen (Anaprox, Naprosyn, others)
      • dalteparin (Fragmin)
      • enoxaparin (Lovenox)
      • heparin
      • warfarin (Coumadin)
      • and others.
    • Other
      • methyldopa (Aldomet)


  • Mental Health
    • Tricyclic Antidepressants
      • amitriptyline (Elavil)
      • imipramine (Tofranil)
      • and others.
    • Phenothiazines
      • chlorpromazine (Thorazine)
      • fluphenazine (Prolixin)
      • trifluoperazine (Stelazine)
      • thioridazine (Mellaril)
      • and others.
    • Antipsychotics
      • chlorpromazine (Thorazine)
      • clozapine (Clozaril)
      • fluphenazine (Prolixin)
      • haloperidol (Haldol)
      • olanzapine (Zyprexa)
      • perphenazine (Trilafon)
      • prochlorperazine (Compazine)
      • quetiapine (Seroquel)
      • risperidone (Risperdal)
      • thioridazine (Mellaril)
      • thiothixene (Navane)
      • and others.
    • Buspirone (BuSpar)
    • Fluoxetine (Prozac)
  • Medications metabolized by the liver:
    • Liver Enzyme 1A2
      • amitriptyline (Elavil)
      • haloperidol (Haldol)
      • ondansetron (Zofran)
      • propranolol (Inderal)
      • theophylline (Theo-Dur, others)
      • verapamil (Calan, Isoptin, others)
      • and others
    • Liver Enzyme 2D6
      • amitriptyline (Elavil)
      • clozapine (Clozaril)
      • codeine
      • desipramine (Norpramin)
      • donepezil (Aricept),
      • fentanyl (Duragesic)
      • flecainide (Tambocor)
      • fluoxetine (Prozac)
      • meperidine (Demerol)
      • methadone (Dolophine)
      • metoprolol (Lopressor, Toprol XL)
      • olanzapine (Zyprexa),
      • ondansetron (Zofran)
      • tramadol (Ultram)
      • trazodone (Desyrel), and others.
    • Liver Enzyme 2C9
      • amitriptyline (Elavil)
      • diazepam (Valium),
      • zileuton (Zyflo)
      • celecoxib (Celebrex)
      • diclofenac (Voltaren)
      • fluvastatin (Lescol)
      • glipizide (Glucotrol)
      • ibuprofen (Advil, Motrin)
      • irbesartan (Avapro)
      • losartan (Cozaar)
      • phenytoin (Dilantin)
      • piroxicam (Feldene)
      • tamoxifen (Nolvadex)
      • tolbutamide (Tolinase)
      • torsemide (Demadex)
      • warfarin (Coumadin), and others
    • Liver Enzyme 2C19
      • omeprazole (Prilosec)
      • lansoprazole (Prevacid)
      • pantoprazole (Protonix)
      • diazepam (Valium)
      • carisoprodol (Soma)
      • nelfinavir (Viracept)
    • Liver Enzyme 3A4
      • lovastatin (Mevacor)
      • clarithromycin (Biaxin)
      • cyclosporine (Neoral, Sandimmune)
      • diltiazem (Cardizem)
      • estrogens
      • indinavir (Crixivan)
      • triazolam (Halcion), and many others.
    • Stimulants
      • diethylpropion (Tenuate)
      • epinephrine
      • phentermine (Ionamin)
      • pseudoephedrine (Sudafed)
      • and many others.
    • Antidiabetic medications
      • glimepiride (Amaryl)
      • glyburide (DiaBeta, Glynase PresTab, Micronase)
      • insulin
      • pioglitazone (Actos)
      • rosiglitazone (Avandia)
      • chlorpropamide (Diabinese)
      • glipizide (Glucotrol)
      • tolbutamide (Orinase)
      • and others
    • Blood Thinners
      • Aspirin
      • clopidogrel (Plavix)
      • diclofenac (Voltaren, Cataflam, others)
      • ibuprofen (Advil, Motrin, others)
      • naproxen (Anaprox, Naprosyn, others)
      • dalteparin (Fragmin)
      • enoxaparin (Lovenox)
      • heparin
      • warfarin (Coumadin)
      • and others.
    • Nitrates
      • nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat)
      • isosorbide (Imdur, Isordil, Sorbitrate)
    • Anti-hypertensives
      • captopril (Capoten)
      • enalapril (Vasotec)
      • losartan (Cozaar)
      • valsartan (Diovan)
      • diltiazem (Cardizem)
      • Amlodipine (Norvasc)
      • hydrochlorothiazide (HydroDiuril)
      • furosemide (Lasix)
    • Seizure Threshold Lowering Drugs
      • anesthesia (propofol, others)
      • antiarrhythmics (mexiletine)
      • antibiotics (amphotericin, penicillin, cephalosporins, imipenem)
      • antidepressants (bupropion, others)
      • antihistamines (cyproheptadine, others)
      • immunosuppressants (cyclosporine)
      • narcotics (fentanyl, others)
      • stimulants (methylphenidate)
      • theophylline
      • and others.
    • Anticonvulsants
      • Phenobarbital
      • primidone (Mysoline)
      • valproic acid (Depakene)
      • gabapentin (Neurontin)
      • carbamazepine (Tegretol)
      • phenytoin (Dilantin)
      • and others.
    • Others
      • Clonidine (Catapres)
      • Guanabenz (Wytensin)
      • Naloxone (Narcan)
      • Alprazolam (Xanax)
      • Efavirenz (Sustiva)
      • Trazodone (Desyrel)
      • sildenafil (Viagra)


  1. https://www.webmd.com/vitamins/ai/ingredientmono-699/horny-goat-weed
  2. https://www.webmd.com/vitamins/ai/ingredientmono-759/yohimbe
  3. https://www.webmd.com/vitamins/ai/ingredientmono-1144/xanthoparmelia
  4. https://www.webmd.com/vitamins/ai/ingredientmono-333/ginkgo
  5. https://www.webmd.com/vitamins/ai/ingredientmono-1098/cnidium
  6. https://examine.com/supplements/mucuna-pruriens/
  7. https://www.webmd.com/vitamins/ai/ingredientmono-1020/cowhage
  8. https://www.webmd.com/vitamins/ai/ingredientmono-1227/butea-superba
  9. https://www.webmd.com/vitamins/ai/ingredientmono-875/l-arginine

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Author: Rob Miller

Rob Miller founded SupplementCritique.com over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.