Arimidione Review: Does It Really Work?

By: Rob Miller
Fact Checked On: 4-24-2021

Home » Prohormones » Arimidione Review: Does It Really Work?

What Is Arimidione?

Developed by a US-based team of fitness, sports nutrition, and medical experts, Arimidione is an over-the-counter, innovative and versatile supplement that can be used as a muscle growth support formula, estrogen blocker, testosterone booster, fat burner, and ergogenic aid (performance enhancer). content/uploads/2020/01/eradicate brand of
Eradicate, brand of Arimistane.

Arimidione is based on a potent, novel, yet medically-backed third-generation aromatase inhibitor (AI) called Androsta 3,5-diene-7, 17-dione ( generic name), branded as Arimistane.

According to Wikipedia, aromatase ( AROM) is an enzyme that converts androgen precursors (e.g. testosterone) to phenols, catalyzing a key aromatisation step in the production of estrogen.

This is why AIs are commonly known as estrogen blockers or estrogen synthesis inhibitors.

Furthermore, according to the study ” Recent Progress in the Discovery of Next Generation Aromatase Inhibitors from the Structure-Function Perspective” conducted by researchers at the State University of New York and published in the Journal of Medicinal Chemistry in 2016, third-generation AIs have high selectivity for cytochrome P450 aromatase (AROM) and low cross-reactivity to any other targets.

What Does Arimidione Claim To Do?

Arimidione claims that it has been specifically formulated to support muscle gains, boost natural testosterone levels and at once minimize estrogen rebound by blocking estrogen production quickly, safely, and effectively. content/uploads/2020/01/golden era muscle
Golden Era Muscle Arimidione.

Image: eBay

This advanced, pharmaceutical-grade anabolic growth formula comes in the form of a specially formulated lotion which is administered topically but delivers the active ingredients transdermally via liposomes.

The formula incorporates the Liposomal Delivery System, a cutting-edge medical micro-needling technology with proven efficiency in deeply penetrating the skin and diffusing the ingredients for fast and optimal absorption into the bloodstream.

Arimidione is made in the US, in a state-of-the-art facility in compliance with current Good Manufacturing Practices (cGMP) standards.

The manufacturer is so confident customers will turn the tables on their hormones and see real, durable results in a short period of time with the use of this innovative anabolic formula that they stand behind it with a full 60-day money back guarantee

Who Is Golden Era Muscle (Now Vintage Muscle)?

Golden Era Muscle (now called Vintage Muscle) is a leading, GP certified sports nutrition manufacturer that produces the top-rated Arimidione formula.

True to its name, Vintage Muscle strives to facilitate the revival of the Golden Era of bodybuilding, drawing inspiration from the glory days of Muscle Beach Venice and the vein-popping, perfectly sculpted bodies of Draper, Columbo, Scott, Howarth, and Schwarzenegger. content/uploads/2020/01/larry
Bodybuilders like Larry Scott relied on good old fashioned diet and supplements to achieve his physique.


According to, supplements were pretty slim (mostly protein and vitamins) back then and the mainstay of the bodybuilders’ diet was eating large amounts of fats and protein yet small amount of carbs (somewhat similar to the keto diet).

In addition to manufacturing Golden Era-inspired anabolics, the Dallas,Texas-based company also provides a suite of educational training programs that nostalgically bring back the classic, tried-and-true bodybuilding training methods.

These classic training programs are given as a complimentary bonus ($97 value) with the purchase of the Muscle Support Stack ( that includes Arimidione and the oral PCT supplement Cycle Support in the form of capsules), the Anabolic Shred Stack or the Alpha Test Stack.

The Golden Era training program ” Mass Muscle Building in Minutes: is available for download on the manufacturer’s official website.

What Are the Arimidione Ingredients?

Arimidione by Golden Era Muscle is a transdermal lotion containing the active ingredient Arimistane as well as pure Aloe Barbadensis Leaf Juice, Inactive ingredients include emulsifying wax NF, glycerin, sorbitol, tocopheryl acetate, and water, according to the label of the supplement.

As aforementioned, the primary bio-active ingredient in this medical-strength, advanced anabolic formula is Arimistane, medically known as Androsta 3,5-diene-7, 17-dione.

You may want to check out our Arimistane review here for more in-depth information on this powerful, third-generation aromatase inhibitor.

How to Use Arimidione

Arimidione is intended for external use only and its route of administration is transdermal.

According to the manufacturer, you should apply 1-2 pumps, to each forearm twice a day (preferably in the morning and in the afternoon).

Rub in completely.

Before applying, ensure your forearms are free from excessive hair and clean.

Also, be sure to avoid swimming, bathing or showering for 3 hours after using Arimidione in order to prevent disrupting the absorption of the formula into the circulatory system.

The formula will not damage or affect tattoos.

Thanks to the Liposomal Delivery System incorporated in this pharmaceutical- grade, highly concentrated anabolic formula (100 mg Arimistane per 1 ml application, 50 ml bottle), the active ingredient Arimistane is optimally absorbed into the bloodstream within 3 hours.

According to Future Science, liposomes represent one of the most effective therapeutic agent carriers, as they have excellent bio-compatibility as well as the capacity to easily interact with cellular membranes and encapsulate various medicine entities.

These nanocarriers are sphere-shaped vesicles consisting of one or more phospholipid bilayers, which are hydrophobic membranes, boasting significantly enhanced efficiency and minimized toxicity.

According to Science Direct, these lipid nano-particles are in fact the first nano-medicine delivery system to make the transition from mere concept to clinical applications.

Golden Era Muscle’s liposome-assisted delivery system is the safer and more convenient alternative to intramuscular injections.

red pct 2.0 review
It’s recommended that you use a PCT (like Red PCT 2.0) in conjunction with Arimidione.

The manufacturer recommends using Arimidione in conjunction with the Post-Cycle Therapy supplement Cycle Support (these capsules should be taken as directed on the bottle).

Cycle Support can be taken after a cycle of prohormones or SARMs to help restore your natural T levels without estrogen dominance.

For an alternative to Cycle Support by Golden Era Muscle, be sure to check out our Red PCT 2.0 review.

(BTW, Red PCT can be used as a PCT supplement or as a standalone natural T booster).

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Arimidione Claimed Benefits

According to the manufacturer Golden Era Muscle’s website, Arimidione is a versatile formula that provides users with a plethora of benefits, including:

  • Increases Muscle Mass and Strength
  • Boosts Natural Testosterone Levels
  • Blocks Estrogen Synthesis and Combats Estrogen Rebound
  • Reduces Cortisol Levels
  • Increases Vascularity and Muscle Hardness
  • Boosts Libido and Improves Stamina and Endurance
  • Enhances Athletic and Sexual Performance
  • Increases Luteinizing Hormone (LH)
  • Reduces Body Fat and Water Retention
  • Shortens Recovery Time and Delays Muscle Fatigue
  • Increases Nitrogen Retention and Energy Levels
  • Improves Mood, Sleep, Cognitive Function and Self-Confidence

Arimidione has been specifically formulated to help minimize estrogen levels while boosting natural testosterone levels and thus combat estrogen rebound.

Estrogen rebound is hard-earned muscle gains’ worst enemy and it occurs when the body converts testosterone into the dreaded estrogen at an enhanced rate, following a cycle with prohormones, T boosters, steroids or SARMs.

The higher the testosterone levels, the higher the estrogen levels, as the body seeks to create a balance of these hormones via the enzyme aromatase.

According to Mayo Clinic, the use of anabolics, androgens or ergogenic aids to enhance workout performance is one of the risk factors of gynecomastia (man boobs). content/uploads/2020/01/before and after gynecomastia
Before and after Gynecomastia surgery.


Other negative effects of high estrogen levels in men include reduced muscle gains, erectile dysfunction (ED), low sex drive, water retention, increased body fat, fatigue, depression, infertility, and even type 2 diabetes, as explained in this University Health News article.

Allowing estrogen rebound to occur is akin to self-sabotage and that’s because it actually sabotages your painstaking lean muscle building efforts and ultimately your goals painfully fast.

This is where Arimidione comes into play, inhibiting the enzyme aromatase that’s responsible for converting testosterone into estrogen.

Thanks to the fact that it effectively blocks the effects of estrogen rebound, known as the muscle gains terminator, while increasing your natural T levels, Arimidione facilitates an optimal anabolic state that enables yo to take your muscle building to the next level and reap the multiple benefits associated with high T and low estrogen and cortisol.

As a result, you will experience multi-beneficial effects such as enhanced gains, increased muscle hardness, definition and vascularity, reduced adipose tissue, improved libido, stamina and performance, among others.

Do the Arimidione Ingredients Work?

As aforementioned, Arimistane, the main bio-active ingredient in this transdermal formula is a powerful, third-generation aromatase inhibitor.

According to this 2016 study, third-generation AIs, that also include Anastrozole ( brand name Arimidex), exemestane ( Aromasin) and letrozole ( Femara) have shown superior efficacy in inhibiting the enzyme aromatase (AROM) and thus blocking estrogen synthesis.

So does Arimidione work?

According to the manufacturer, Arimidione really works, more specifically via Arimistane’s proven mechanism of action.

Golden Era Muscle guarantees that users will see visible results in a short period of time or their money back.

The fact that the formula is backed by a full 60-day money back guarantee further proves its fast action and superior efficacy.

According to, Androsta 3,5-diene-7, 17-dione (Arimistane) is a naturally-occurring metabolite of 7-Keto Dehydroepiandrosterone (DHEA), which is why it is also known as 3-deoxy- 7-Keto DHEA (DHEA is a hormone with testosterone-boosting and anti-aging properties and DHEA supplements can be used in conjunction with aromatase inhibitors).

This natural metabolite is the result of a single bond between carbons 3 and 4 turning into a double bond (hence the designation “dien”) and it’s found in the urine, as this change from 7-Oxo ( i.e. the double bond) appears to occur in the liver, under various conditions of hydrolysis, according to research.

Furthermore, Examine suggests that Arimistane possesses competitive aromatase inhibiting abilities, based on limited clinical studies such as this study published in J. Med.


Arimistane is an irreversible, type I aromatase inhibitor structurally similar to the exemestane, branded as Aromasin, which is administered orally and is used primarily for the treatment of Estrogen Receptor (ER)-positive breast cancer.

Arimistane is also known as a”suicide AI”, as it permanently binds to the AROM enzyme and causes enzyme inactivation, preventing any estrogen rebound and thus resulting in higher testosterone levels.

In addition to blocking estrogen production, this AI also significantly reduces the levels of cortisol.

According to Research Gate, high levels of cortisol in the body are associated with catabolic (muscle losing) effects and increased body fat.

Arimidione also works as a standalone natural testosterone booster that works by stimulating the pituitary gland to produce more Luteinizing Hormone, thus raising LH.

According to WebMD, the symptoms associated with low LH in men include low T levels, low libido and decreased muscle mass.

According to Golden Era Muscle’s website, the bio-active ingredient in the multi-beneficial anabolic growth formula Arimidione is encapsulated by the Liposomal Delivery System, consisting of 3 steps:

1. Microneedles penetrate the stratum corneum ( the outermost layer of the skin)

2. Arimistane moves through diffusion from high to low concentration

3. Arimistane is absorbed locally, then transported into the systemic blood circulation.

According to Wiki, liposomes work to deliver the active ingredient by diffusion rather than direct cell fusion.

Therefore, Arimistane is delivered across the skin into the bloodstream.

The Liposomal Delivery System is an highly advanced drug delivery technology that optimizes the active ingredient’s bioavailability, facilitating complete and fast absorption into the system so it can work efficiently.

According to the 2015 study “Transdermal Delivery of Drugs with Microneedles“, the benefits of transdermal drug delivery include elimination of first-pass inactivation in the liver, sustained release and avoidance of gastric irritation.

With this advanced technology, the drug is no longer involved in the first-pass effect, as it is delivered via the lymphatic route.

Arimistane is thus fully absorbed into the systemic circulation, helping maintain elevated T levels and low estrogen levels.

Furthermore, according to another 2015 study, “Advances and Challenges of Liposome Assisted Drug Delivery“, the unique ability of liposomal delivery systems to entrap both lipophilic and hydrophilic compounds enables a wide range of drug to be encapsulated by these spherical vesicles.

According to LiveStrong, Aloe Barbadensis, commonly known as Aloe Vera has been used for centuries to treat various skin conditions and injuries, including burns and sunburn, psoriasis, herpes, as well as skin irritation, inflammation and redness thanks to its powerful anti-inflammatory, soothing, antioxidant, and collagen-boosting properties.

Arimidione also contains Aloe Vera leaf juice which is extracted from the plant’s water-filled, slimy tissue.

According to Medical News Today, this leaf juice contains most of the bio-active compounds in Aloe Vera (e.g. vitamins, minerals, antioxidants and amino-acids), with multi-beneficial effects on the skin and overall health.

Arimidione Side Effects

No adverse effects have been reported by Arimidione users when administered as directed.

Whereas androgen replacement therapy such as intramuscular injections with synthetic esters of testosterone (e.g. testosterone cypionate) have been associated with many side effects as well as an increased risk of heart disease and prostate cancer, this natural T booster, estrogen blocker and anabolic growth supplement hasn’t been linked to harmful effects, as long as the recommended dose of up to 2 pumps twice a day is not exceeded.

Given the high concentration and potency of this formula, it’s especially important to use it responsibly, according to directions, so as to avoid potential side effects.

The manufacturer warns that Arimidione is not intended for use by individuals under the age of 18.

Likewise, people who undergo treatment for a medical condition (e.g. diabetes, heart, kidney or liver disease, neurodegenerative disorders, etc.) should advisedly consult their healthcare provider before using Arimidione, as the high concentration of Arimistane may interfere with their medication, either amplifying or reducing its effects.

Arimidione Reviews

Owning to the fact that this pharmaceutical-grade anabolic and hormone optimizer is relatively new on the market, there are not a lot of Arimidione reviews out there, but those found online are all positive and appear to validate the manufacturer’s claims.

Jake L. says “so far so good”; after just a week of using Arimidione, he is sleeping great and has in fact added to his lift numbers, much to his surprise, Jake explains this is the third time using a prohormone and the first two times experienced significant losses in both size and lift numbers the first week using a much more expensive PCT supplement.

Andrew is another user who is happy with this formula, saying that his blood work has proven on several occasions that Arimidione is great for keeping both estrogen and cortisol levels at a minimum.

In another review from 2018, a customer admits that he has used Arimidione religiously on SARM and prohormone cycles and it has worked wonders for him, without any adverse effects.

The fact that Arimidione is also an excellent value for the dosing is another reason why he’ll definitely keep buying it to reach his muscle building goals.

Based on these Arimidione reviews, it appears that Arimidione is an effective and safe anabolic formula and estrogen blocker that works fast, as users have seen visible results in as little as 1 week.

Where to Buy Arimidione

Men who are looking for a competitive edge that can help them maximize their potential and turn the tables on their hormones can conveniently and securely purchase this maximum strength, medically backed anabolic growth formula exclusively from the manufacturer’s official website.

As of this Armidione review, this revolutionary Liposomal Delivery System lotion is not available on Amazon / other major retailers or in stores.

If you decide to purchase this anabolic formula that you can use as a PCT supplement or hormone optimizer, you can benefit from a great deal, as Armidione is currently available at nearly half the price.

You can thus save $40 and purchase it for only $57 (this is most likely for a limited time only).

If you choose to buy the Muscle Support Stack by Golden Era Muscle that includes both Arimidione and Cycle Support, you can save a whopping $153 and get both supplements for as little as $67.

By all means, this is an incredible offer, even though chances are it’s a limited one.

When you order Arimidione from Golden Era Muscle website, it is a one-time charge.

There isn’t an automatic refill program where you will be billed monthly, so rest assured there are no hidden fees or transactions.

It’s up to you how many bottles of Arimidione you want to purchase, depending on your muscle building goals.

Every bottle of Arimidione (50 ml) last you 60 applications, so up to 1.5 months, depending on the dosing of your choice (1 or 2 pumps twice a day).

Non-US residents can also order this formula, as the manufacturer also ships outside the US.


After reading our impartial Arimidione review. you may ask yourself is Arimidione really worth buying?

Based on the high concentration, increased bioavailability, and highly efficient (liposome-assisted) delivery of the formula’s scientifically proven active ingredient Arimistane with anabolic growth , testosterone-boosting, estrogen-blocking and fat-burning properties, and coupled with our research and the positive user reviews found online, we conclude that Arimidione is worth a try, to say the least.

There are many glowingly positive benefits that can come from taking it and based upon the positive experiences of many users across the world that have reported it having very great results, I think that trying Arimidione is not only a good idea, but that it is possibly an essential for products of this kind.

This advanced, pharmaceutical-grade anabolic growth and estrogen control formula helps optimize the body into a distinctly anabolic environment, so as to support new muscle gains quickly and safely, without estrogen and cortisol getting in the way of your muscle building goals.

Arimidione thus ensures that all muscle gains are properly maintained once cycled off prohormones or SARMs and hormones are optimized for future gains.

The fact that Arimidione is currently heavily discounted (you pay just $57 for the 50ml bottle or $67 if you buy the Muscle Support Stack so you can use Arimidione transdermal lotion in junction with the PCT Cycle Support (capsules) certainly doesn’t hurt, making for a more affordable try.

Furthermore, the manufacturer Golden Era Muscle guarantees visible results within a short period of time or your money back, offering a full 60-day money back guarantee with each purchase, so you have nothing to lose.

If for some reason, you are not happy with your purchase, simply contact Golden Era Muscle and you will get a refund, no questions asked.

If you want to further educate yourself about the best bodybuilding supplements that mimic the effects of powerful steroids, but without the typical adverse effects associated with using them, then be sure to check out our in-depth article here.

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Author: Rob Miller

Supplement Critique

Rob Miller founded over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.

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