NutraBio Arginine Pyroglutamate Lysine Review – Does It Work?

By: Rob Miller
Fact Checked On: 4-5-2018

Home » Hgh Supplements » NutraBio Arginine Pyroglutamate Lysine Review – Does It Work?

With all the scientific advancements of the last century, is it time to start believing that we can live significantly longer, significantly healthier lives?

In a lot of ways, we already do, but we’re talking about fountain of youth type stuff here.

These days, if you have enough money, you can get injections of synthetic Human Growth Hormone (HGH) prescribed by a doctor.

While these injections are primarily used for children and others with growth and development disorders, some doctors who specialize in anti-aging treatments use them to help their patients look and feel decades younger.

But as we mentioned above, if you’ve got enough expendable cash and access to an anti-aging specialist, you can benefit from this particular scientific advancement.

If not, there still may be hope.

What is NutraBio Arginine Pyroglutamate Lysine?

You’re probably familiar with L-Arginine as a popular ingredient in workout supplements.

That’s because as a pre cursor to nitric oxide, it helps improve blood flow to your muscles for better nutrient and oxygen delivery.

With more oxygen and nutrients in your muscles, they can work harder, recover faster, and get bigger than with less.

When you add Pyroglutamate to your L-Arginine, you allow it to cross the blood-brain barrier, which means that now your brain gets the same benefits of increased oxygen and nutrients that your muscles get.

For this reason, you sometimes find L-Arginine Pyroglutamate in cognitive enhancement supplements.

But there’s an even bigger potential benefit to a product calledNutraBio Arginine Pyroglutamate Lysine, and that’s its effect on HGH.

NutraBio Arginine Pyroglutamate Lysine Review 2NutraBio Arginine Pyroglutamate Lysine and HGH

L-Arginine has long been considered to have an effect on the body’s natural release of HGH.

But there’s really very little evidence, most of it anecdotal.

That changes to a degree when you introduce Pyrogluatamate and Lysine.

There is some spotty evidence that using Arginine Pyrogluatamate with Lysine may increase HGH levels.

But there’s also evidence that it doesn’t.

At this point, without definitive evidence either way, it kind of depends on which studies you choose to believe.

How NutraBio Arginine Pyroglutamate Lysine Works

If you accept that you can increase serum levels of HGH using supplementation, here’s how it works.

L-Arginine, taken in large doses (10-30 grams) on an empty stomach stimulates the release of HGH.

Since HGH release occurs mainly while sleeping, it’s recommended you take it close to bedtime, about 3 hours after your last meal.

Partly because of the ability to cross the blood brain barrier, dosing needs with NutraBio Arginine Pyroglutamate Lysine are much smaller.

You only need 1200 mg of Arginine Pyroglutamate and 1200 mg of Lysine for the same effect.

Another reason for this drastic difference is the way all three molecules interact with receptors.

L-Arginine and L-Lysine compete for the same receptors.

Add the Pyroglutamate molecule, and that’s no longer the case.

Clinical Studies

The most important favorable study was done back in 1981 by Italian scientist A. Isadori, M.D. It was a small study of only 15 males ages 15 to 20, and showed that with L-Arginine Pyroglutamate and L-Lysine at these doses, subjects gained 10 times more HGH in their blood than with L-Arginine alone.

This translated to a 700% increase in serum HGH.

Unfortunately, this study has not been wholly replicated since then. So while there’s hope that this combination works, there’s not conclusive proof.

Perhaps even more importantly, no studies exist to demonstrate the positive effects of these increases in HGH levels.

Most of the big increases occur in young males, who already have an abundance of HGH.

With no deficit to reverse, it’s tough to see what benefits it might have.

We know theoretically what should occur, and with injections, it can be seen anecdotally.

But there’s no real evidence of the benefits you would hope for when using NutraBio Arginine Pyroglutamate Lysine supplementation.

NutraBio Arginine Pyroglutamate Lysine ReviewNutraBio Arginine Pyroglutamate Lysine Ingredients

The supplement profile is very simple and uses only what it deems necessary to get the supposed benefits.


  • 1200mg of L-Arginine Pyroglutamate, and
  • 1200mg of L-Lysine.

NutraBio Arginine Pyroglutamate Lysine comes in both pill and powder form so you can choose which one to use based solely on personal preference.

If you’re using capsules, take 4 on an empty stomach before bed.

If you’re using the powder, mix one scoop with water on an empty stomach before bed.

NutraBio Arginine Pyroglutamate Lysine Pros and Cons

Advantages of NutraBio Arginine Pyroglutamate Lysine

  • The formula is based on scientific belief and only uses the relevant ingredients with no fillers.
  • There is some scientific basis to the claims.
  • The ingredient profile and dosage levels are openly disclosed.
  • It’s inexpensive to try.

Disadvantages of NutraBio Arginine Pyroglutamate Lysine

Where to Buy

You can purchase NutraBio Arginine Pyroglutamate Lysine through the NutraBio website.

A 150 gram tub contains 62 servings and costs only 16.99. The capsules are a little more expensive.

A 37-serving bottle costs $15.99. It’s also available on Amazon if you prefer.


This is a tricky one.I don’t believe there’s a simple way to significantly boost HGH in your body.

HGH secretagogues can help you with energy, fat loss, lean muscle retention, etc, but the evidence doesn’t support the elevation of actually serum levels.

With NutraBio Arginine Pyroglutamate Lysine, there is some hopeful evidence.

But it’s from 35 years ago, and it hasn’t been successfully repeated since then. (Not to mention the test was done on teenagers, who arguably don’t need to increase their HGH.)

With all of that said, NutraBio Arginine Pyroglutamate Lysine is inexpensive and shows some potential benefits in addition to HGH.

It may improve cognitive function, and you may get the simple L-Arginine benefits of better workouts and recovery.

All in all, if you have an interest in what might increase HGH, give NutraBio Arginine Pyroglutamate Lysine a try.

Have You Used NutraBio Arginine Pyroglutamate Lysine?

Leave Your Review Below!

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Author: Rob Miller

Supplement Critique

Rob Miller founded over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.

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