Xenadrine Review – Does It Work?

By: Rob Miller
1 User Reviews
Fact Checked On: 3-27-2020

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The number of weight loss supplements on the market can be literally dizzying. No wonder it’s so hard to pick on and go with it.

With thousands of choices, how are you supposed to know which is the best? Well, that’s why we’re here, doing our best to break it down and make it as simple as possible to choose.

Today we’re taking a look at Xenadrine Ultimate, which is one of the most popular weight loss pills found in Walmart and other stores.

The name “Xenadrine” has been around for years now, and they make a wide variety of competing weight loss pills including Xenadrine Core and Ultimate.

It was popular back in the Ephedra days. But of course, that’s been banned for a while now.

That brought about a lot of changes to the weight loss supplement industry of course and it caused many brands to shift gears and come up with new formulas.

So let’s find out what’s in it now and whether or not it works to help you take the weight off.

Watch Our Video Review Or Scroll Down To Read More

Xenadrine Ultimate Ingredients and How They Work

Ephedrine was effective, there’s no doubt about that.

It’s been around in one form or another for quite a long time. Back in the late 90’s and early 2,000’s, it was actually my go-to fat burner.  I went from a hefty 196 lbs. to an ABSOLUTELY shredded 168 lbs. in a matter of 3 months when it contained Ephedrine.

I literally went from this:

xenadrine ultimate before and after

To this:


In a matter of months.

But its safety was called into question when poison control center visits went up DRAMATICALLY in the early 2000’s, and 13 people actually DIED from products containing it.

This led the FDA to ban ephedrines use as a weight loss supplement in 2004, a result that was actually overturned by the weight loss industry in 2005, but later upheld by the US court of appeals in 2006.

So weight loss supplement companies had to scramble to come up with something else to do the trick.

In the case of Xenadrine Ultimate, they largely rely on Caffeine to speed the metabolism, provide energy, and suppress the appetite. It sounds pretty basic and old school, but when combined with a cast of supporting ingredients, it actually can be pretty effective.

The Xenadrine Ultimate weight loss formula is broken up into 2 parts:

Weight Loss and Metabolic Intensity Complex

  • Robusta Coffee Bean Extract:  This is basically a fancy name for Coffee Bean extract.  It’s primary benefit regarding weight loss is to inhibit fat accumulation and modulate glucose metabolism, however, scientific studies on these reported benefits are generally regarded as weak. (1)
  • Caffeine Anhydrous:  We all know what caffeine is and does.
  • Yohimbe Bark Extract:  A very powerful ingredient that is found in everything from fat burners to male sexual enhancement products, Yohimbe is a stimulant that acts as a powerful aphrodisiac. (2)

and the Xenadrine Ultimate Complex

  • Garcinia Fruit Extract:  Some studies have suggested that, because Garcinia contains the chemical Hydroxycitric Acid, that it may help to prevent fat storage, control appetite, and increase exercise endurance. (3)
  • L-Theanine:  An amino acid that neutralizes the effects of stimulants, and promotes feelings of calm.  It is especially useful when combined with Caffeine, and is said to promote enhanced cognitive effects. (4)
  • Spearmint Leaf Extract:  While not exclusively a weight loss ingredient, it’s said that Spearmint extract can help with digestion by relaxing stomach muscles. (5) This in turn reduces symptoms of nausea, which just so happens to be a very common side effect of Yohimbe. (which is why they probably added it)
  • Autumn Olive Fruit Extract:  The addition of this ingredient is a bit of a mystery to me at first, and I couldn’t find much in the way of benefits of it during my research.  Wiki has a page on it, and according to them it contains a 7 – 17 times higher content of Lycopene than an average tomato. (6)  If you weren’t already aware, Lycopene is a strong antioxidant that has numerous benefits.
  • Ashwagandha Root and Leaf extract:  While more commonly used in male sexual enhancement supplements, Ashwagandha Root and Leaf extract has also been shown to help relieve anxiety, and to help the body cope with stress (7)

Here’s a snapshot of the label:

xenadrine ultimate ingredients label

As you can see, there’s a ton of Caffeine in Xenadrine Ultimate.  200 mg per serving to be exact, which is about double the caffeine content in a standard cup of coffee.

how much caffeine in xenadrine ultimate

With the addition of Yohimbe, which is a powerful stimulant as well, this can make for a very jittery experience.  Clearly if you are sensitive to stimulants you may want to pass on this one.

The recommended dose reflects caution:

how to take xenadrine ultimate

As you can see, they specifically state that you should take 1 serving twice daily for the first few days.  In order to get the best effects, it’s defintely a good idea to take Xenadrine Ultimate on an empty stomach about 30 – 60 minutes before main meals.

On days 4 and beyond, it’s suggested that you take 2 capsules twice per day.

Don’t force yourself to do this!

Listen to your body.  If the jitters are too much, or you just overall feel uncomfortable, I would not recommend upping your dose like this.

According to them, in 2 scientific research studies involving their key ingredient Coffee Robusta, participants on average saw

  • A reduction in weight by 10.9 lbs. vs. 5.4 lbs. by a placebo group in a 60 day study, and
  • A 3.7 vs. 1.2 lbs. by a placebo group in a separate 8 week study

xenadrine ultimate clinical study

Both studies included a calorie reduced diet and moderate exercise, and you can read both of them here.

Xenadrine 21-Day Starter Plan

One of the best things Xenadrine Ultimate has going for them is their 21-Day starter plan.  For someone like myself, who has been into diet and exercise since I was like 16 years old, this information is not very informative.

HOWEVER, for someone who is just starting out and is unsure of how to approach weight loss effectively, this information is gold.

xenadrine ultimate 21 day starter plan

They break out their 21-day plan into Strength days, Cardio Days, and Rest Days, outlining what you should be doing on each day.

Their nutrition plan includes a breakdown of daily protein, fat, and carbs requirements based on a 1500 calorie diet, which of course should be tailored to each individual based on their own calorie needs.

xenadrine nutrition plan

They provide healthy meal plans, which include the exact ingredients needed.

The only downside is they don’t give specific instructions on how to cook these items, however, any decent cook will be able to figure it out on their own.

My Personal Results

xenadrine ultimate reviewIt’s been quite a while since I tested a weight loss supplement, and I figured since I needed to lose about 8 pounds I put on over the winter, this would be a good test.  As with any stimulant-heavy supplement, I decided I would start off with just 1 capsule per day for the first few days, and then gradually work my way up.

I skipped my usual cup of coffee this particular morning, and instead popped one of the capsules (which are surprisingly large).  I could definitely start to feel the effects kick in within about 20 minutes, and by the one hour mark it seemed to have peaked.

The first thing I noticed was any hunger pangs I had were completely eliminated.

I didn’t feel hungry AT ALL for a good 2 hours.

Another thing I noticed was a slight sense of nausea, which again, is very common with products containing yohimbe.

It wasn’t a debilitating nausea, but a slightly uncomfortable one.

For that first day I would say the effects lasted about 3 hours and then started to taper off.

After a few days of just taking 1 pill, I decided to take 2 in the morning.  I though about dividing up the dose by taking 1 pill first thing in the am, and then another one later in the day, but didn’t want to risk getting insomnia.

Just like on the first day, I felt it kick in after about 20 minutes, HOWEVER this time the effects were much more pronounced.

In fact, they felt like they were doubled (no surprise there, right?)

I decided to go to the gym early that day, and what followed was one of the most intense workouts I’ve had in a long time.

I could literally feel the energy surging through my body, and after a 45 minute weight lifting session I found myself on the treadmill for a quick 5K.

About 4 hours later is when I felt the crash.

It wasn’t the type of crash I’ve gotten with other supplements like Zantrex Black and Fastin, but a crash nonetheless.

All in all, I took Xenadrine Ultimate for about 2 weeks and dropped about 6 lbs.

Not bad, considering I didn’t really change up my diet.

Other Xenadrine Ultimate Reviews

All in all, feedback for Xendarine Ultimate is mixed, which is not surprising for a weight loss supplement.  Out of the 152 reviews currently on Amazon, a slight majority of 51% of people rated it 5 stars.

Almost all of the reviews had the following benefits:

  • Curbed appetite (this one is mentioned constantly)
  • Increased energy

The only useful video review I found was on Youtube:

[youtube https://www.youtube.com/watch?v=PTigBmPD5GM]

Some of the most commonly reported Xenadrine Ultimate side effects include:  Headaches, Insomnia, Stomach Cramps, Diarrhea, Anxiety attacks, Increased heart rate, and chest pains.  These are no doubt caused by the Caffeine and Yohimbe content contained in the supplement.

Xenadrine Pros and Cons

Advantages of Xenadrine

  • I’ve personally tested it, with favorable results.
  • There are lots of reviews from happy customers who say it works.
  • Xenadrine has undergone a couple of clinical tests showing that it works far better than a placebo when used in conjunction with a reduced calorie diet and exercise program.
  • It’s relatively inexpensive to try.
  • You can find it conveniently in stores near you, as well as online.

Disadvantages of Xenadrine

  • Some people experience stimulant-related side effects with Xenadrine.
  • A bottle only lasts 10 days when used at full dose as directed.
  • There are several Xenadrine reviews complaining that it just doesn’t work.

Where to Buy

Xenadrine is in drug stores, big box stores like Walmart, as well as online. The 60 capsule bottle sells for about $25, and I didn’t see any evidence of a money back guarantee.


In conclusion, I have to say that Xenadrine Ultimate does indeed WORK!

Does it work better than the original formula?

I don’t personally think so.

After all, the original formula featured an ingredient that was so good that it got put in every other supplement of its kind before eventually being banned, so a dip in quality is expected but it is a good supplement never the less.

However, it does seem to curb appetite, as well as help provide increased energy for physical activity.

It’s not a miracle weight loss supplement.

In fact, there are no “miracle weight loss supplements”, at least none that I’ve tested.

But if you are committed to leading a healthy lifestyle which includes diet and exercise, Xenadrine Ultimate will help you get there.

If you do well with stimulants, Xenadrine may very well work for you. Make sure to start off slowly, though, to give yourself a chance to find out how you’ll be effected. I like that they emphasize a healthy diet and exercise program to go along with the Xenadrine because those are the real keys to weight loss. Supplements like Xenadrine help, but it’s the commitment on your part that really determines your success.

Have You Used Xenadrine? Leave Your Review Below!

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Author: Rob Miller

Supplement Critique

Rob Miller founded SupplementCritique.com over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.

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