Vigrx Plus RX Interactions And Frequently Asked Medical Questions

Author: Dr. Brian Straub, Pharm.D.
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Possible Prescription Drug Interactions and Medical Warnings For Vigrx Plus

Vigrx Plus is one of the most popular supplements we’ve reviewed on SupplementCritique.com.

I get dozens of questions every month from a wide variety of visitors asking about potential prescription drug and medical interactions.

We’ve hired a pharmacist who has answered these questions below.

At the bottom of the post you’ll see a full list of drugs that can possibly interact with Vigrx Plus.

Can I take Vigrx Plus if I have high blood pressure?

  • There appear to be no negative interactions for those with high blood pressure.

    If you are taking blood pressure medications, use caution, as this supplement may also lower blood pressure.

Can I take Vigrx Plus if I have LOW blood pressure?

  • Many of the ingredients in this supplement may cause an unsafe drop in blood pressure for those already with low blood pressure.

Can I take Vigrx Plus if I have diabetes?

  • Many of the ingredients may lower blood sugar and alter the effects of insulin.

    When adding a new supplement that may lower blood sugar, it is best to monitor your blood sugar daily for the first week.

    If you experience hypoglycemia, stop the supplement and speak with your doctor about possibly altering your regimen.

Are allergic reactions possible with Vigrx Plus?

  • As with all supplements and medications there is the possibility of allergic reactions.

    There are no allergic reactions that stand out with this combination.

Can I take Vigrx Plus with alcohol?

  • As it is best to avoid alcohol when taking supplements, the only known interaction is with the Ginseng.

    Ginseng may increase how fast your body breaks down alcohol.

    Use caution when consuming alcohol.

Can I take Vigrx Plus with Viagra / Cialis?

  • This may cause an unsafe decrease in blood pressure.

Can I take if I am taking anti-depressants?

  • Some ingredients in this product may increase nervousness, jitters and possibly induce hypomania in those patients with mental disorders.

    Avoid use of this product if you are taking MAOI’s: phenelzine (Nardil), tranylcypromine (Parnate), and others.

Can I take if I have a bleeding disorder?

  • A few of the ingredients in this product may decrease your body’s clotting ability (thin your blood).

Can I take with Caffeine or other stimulants?

  • A few of the ingredients in this supplement may stimulate the nervous system.

    Taking in combination with caffeine and other products including pseudoephedrine may increase jitteriness, nervousness, increased heart rate and high blood pressure.

Possible Drug Interactions:

Major

  • Blood Thinners and Antiplatelets:
    • NSAIDS
      • ibuprofen
      • naproxen
    • Aspirin
    • Coumadin (warfarin)
    • Plavix (clipidogrel)
  • Seizure medications
    • Dilantin (phenytoin)
    • carbamazepine,
  • Cardiac Medications
    • digoxin,
    • beta blockers
      • metoprolol
      • propranolol
    • calcium channel blockers,
      • Norvasc (amlodipine)
      • diltiazem
    • Nitrates
      • Nitrostat
      • Imdur (isosorbide)

Moderate

  • Mental Health
    • Lithium
    • Zoloft (sertraline)
    • Lexapro (escitalopram) and other SSRI’s
  • Anti-Seizure (or medications that lower seizure threshold)
    • Phenobarbitalprimidone
    • Depaken (valproic acid)
    • Neurontin (gabapentin)
    • Tegretol (carbamazepine)
    • Dilantin (phenytoin)
    • Propofol
    • Mexiletine
  • Certain Antibiotics
    • Penicillin
    • cephalosporins
  • Antidibetic medications
  • Auto-Immune Medications (immunosuppressants for transplant, rheumatoid arthritis, psoriasis, etc.)
  • Medications metabolized by the liver:
    • Liver Enzyme 2C19
      • amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin (Coumadin), and many others.)
    • Liver Enzyme 2C9
      • amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.
    • Liver Enzyme 2D6
      • amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
    • Liver Enzyme 3A4
      • amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
    • Liver Enzyme 3A6
      • lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and others.
    • Others
      • Trazadone

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Author: Dr. Brian Straub, Pharm.D.

Brian Straub is a medical science liaison and licensed clinical pharmacist. He graduated from the University of Pittsburgh School of Pharmacy in 2011, and is also a registered yoga instructor.