Arthrozene Review

By: Rob Miller
21 User Reviews
MD Reviewed By: Helen Okoye, MD What's This?
Fact Checked On: 3-18-2020
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Listen to my audio review:

Update (9-14-2018):  We had a gentleman named Jim O’Donnell test out Arthrozene.

Click Here
 to follow along on his daily results diary.

There’s no doubt about it, joint pain sucks.

It’s inevitable as we age, and only seems to get worse as the years tick by.

There’s certainly no shortage of joint relief supplements flooding the market, some of which we’ve actually tested.

Some, like Instaflex, actually worked really well.

instaflex review
My brother-in-law tested Instaflex. 2 thumbs up from him

Others, not so much.

I first came across Arthrozene when I was scrolling through my Yahoo news feed.

arthrozene ad - it's like wd-40 for your knees

I, in fact, do have joint pain, so whenever I see an ad like this I usually click.

It took me to a page on the Arthrozene website that suggested most people are making a mistake when it comes to joint pain.

What’s the #1 mistake?

Trying to “mask” the pain by just simply popping an Ibuprofen or Advil.

I tend to agree with them on this point.  Most Americans (myself included) tend to treat a problem by simply popping a pill, rather than trying to identify the root cause and fix it.

Not only does long term use of Ibuprofen and other medications cause potential liver and gut issues over time, it is essentially putting a band aid on something that will not get better without proper help.

But will this pill tackle the root cause of your joint pain?

And if it does, how does it do it?

Let’s find out.

Watch Our Video Review Or Scroll Down To Read More


1.  What is Arthrozene?

There are a wide variety of root causes of joint pain, including:

  • Arthritis
  • Fibromyalgia
  • Gout
  • Osteoarthritis
  • Tendinitis

According to the products website, Arthrozene is a 3-step solution that attacks those root causes.

2.  How does Arthrozene work?

Details are a bit vague, but according to them their formula is designed to do 3 things:

  1. Decrease inflammation
  2. Slow down cartilage degradation
  3. Increase lubrication

It does this through the application of their all-natural formula, which we’ll discuss in detail below.

3.  What are the ingredients in Arthrozene?

Most joint supplements contain one ingredient and one ingredient only, and that’s Glucosamine.

This one is different…

According to the label, Arthrozene contains 3 key ingredients.  These include:

  • ApresFlex Boswellia Serrata Extract
  • Mobilee Naturak Chicken Comb extract
  • B-2Cool Native Collagen type II

Click Here to see a snapshot of the label.

Since I haven’t done a tone of research on joint pain / relief pills in general, I actually had to dig in a bit to find out what these ingredients were all about.

ApresFlex Boswellia Serrata

This is essentially a trademarked version of Boswellia Serrata, a type of tree found in India and Arabia.

There’s a type of sap that seeps out from openings in the bark, which is called Indian Frankincense.

It’s been clinically studied as an anti-inflammatory agent, among other things.

You can read the details of one such clinical study here.

Mobilee Naturak Chicken Comb Extract

This is another clinically tested substance that’s been designed to help specifically with joint pain.

Since Chicken Combs contain high amounts of Hyaluronic Acid, it’s been shown to act as an all natural lubricant for joints.

As a result, it can provide significant pain relief, especially for those suffering from Knee Osteoarthritis.

B-2Cool Native Collagen type II

The third ingredient in Arthrozene, B-2Cool Native Collagen type II, basically acts to improve tissue strength in your joints, as well as tensile strength.

According to published research, native Collagen type II has been shown to be effective in treating symptoms of osteoarthritis.

What does this mean?

Well, it will help to repair cartilage as well as make it stronger.

4.  Are there any side effects?

As with any supplement, side effects are possible.

For example, Boswellian Serrata has been shown to cause adverse effects in some people.

As reported by WebMD, these include:

  • Stomach pain
  • Nausea
  • Diarrhea

HOWEVER, it should be noted that these side effects are VERY RARE, and are only reported in a small percentage of people that have taken the extract.

From what I’ve researched, the 2 other ingredients in Arthrozene do not cause any adverse effects to be worried about.

If you’re thinking about taking this supplement, I would of course advise you consult with your doctor first.

There may be some drug interactions that I’m not aware of, and only he / she would know for sure.

5.  Who Makes Arthrozene?

According to their contact page, it’s made by a company called Fisico Inc.

Located in Westford, Massachusetts, they make numerous other brands, including:

  • The Cruise Control Diet
  • SlimBiotine
  • Cerebra

I’ve never heard of these other supplements before, so I can’t comment on them.

They have a A rating with the BBB, with mostly positive reviews.

6.  What do the Arthrozene Reviews have to say?

Since we initially wrote this review, we’ve had 17 people leave their Arthrozene review on our site.

Click Here to read them.

7.  STEPuP Program Test

As part of our STEPuP program, we currently have a gentleman named Jim testing out Arthrozene. content/uploads/2018/06/jim testing

He’s a 66 year old man that has been involved in sports all his life.  See his story below:

I would be interested in testing Arthrozene. I am 66 and have been involved in sports all my life. Both knees are worn.  Close to bone on bone on one knee and the other is not far behind. Have had 1 or 2 shots and have talked to stem cell people. Would like to avoid knee surgery as much as I can. Just reduced swelling and a little more flexibility would allow me to ride my bike again which could/would help to build the leg muscles back up. Sounds like Arthrozene might be an option. I could certainly give you a day by day. Thanks.

And here’s his daily results so far:

12-Sep:  Received and took first pill Wednesday night 9/12.
13-Sep:  No change.
14-Sep:  As of Friday – do not seem to see any results.
15-Sep:  Normal discomfort – no change. Kneecaps are tender.
16-Sep:  Seems to be slightly more discomfort than normal. Kneecaps are tender – could be due to use on Saturday.
17-Sep:  No better than normal discomfort.
18-Sep:  Hoping for improvement but cannot feel it yet.
19-Sep:  First notice that discomfort might be better then normal, but stiffness in right knee continues. Tenderness in kneecaps seems less.
20-Sep: Knees seem to be slightly better, almost as if receiving a pain killing shot.
21-Sep: Knee is OK but stiffness and swelling remains.
22-Sep: Tenderness in kneecaps returns after being much less since Wednesday.
23-Sep: Knees are close to what they had been in last 3- 4 weeks, tenderness in kneecaps and general soreness in knees.
24-Sep: Knee caps and knees are tender and sore this morning. Left knee is loose when crossing knees at work.
25-Sep: Knees remain tender, stiff and normally unstable. Sleeping uncomfortably seems to be better.
26-Sep: No noticeable change.
27-Sep: Lot of stairs at work today. Stiffness and flexibility are not getting any better/maybe worse.

Final thoughts

I was optimistic about Arthrozene and hoped/wished that it would delivery what was being suggested.  I took the pills religiously and as I mentioned about 8-9 days in I seemed to feel less discomfort.  But when the next weekend came I went back to my old condition and it never changed or improved from then to the end of the product.  Because I had not monitored myself as closely as I did during these 30 days I may have not noticed that due to less usage of my legs/knees during the week I felt better during that time but then felt more discomfort on the weekends when I used my legs/knees more.   This may have lent to the improvement I seemed to feel after 8 – 9 days.  I cannot rule out that Arthrozene may have prevented my knees from getting worse during this time, but I truly did not see any noticeable improvement.

7.  My Personal Results

arthrozene review

So I finally got a chance to try out Arthrozene for the last 2 weeks, and I have to say I actually think it’s working.

For those of you that haven’t been following my reviews, I’m a 36 year old amateur professional beach volleyball player.

I’ve been playing since I was about 14 years old, and I can’t begin to tell you what kind of an impact the sport has on your joints.

The constant sprinting and jumping can really start to wear you down, especially if you’re doing it all in deep sand 4 – 5 days a week.

Wasn’t a problem when I was in my early 20’s, but we all know how that goes 🙂

I received a 30 count bottle of Arthrozene about 10 days ago, and I’ve been taking it on an empty stomach everyday.

For the first few days I didn’t notice much of anything.

I generally will take 2 advil upon waking up, and 2 about an hour before bed to aid with some of the pain.

Within about a week of taking Arthrozene, I started to notice that I really didn’t need that evening dose.

I didn’t even realize it until one night I was reading and realized that I hadn’t taken any Advil, but didn’t really have the usual aches and pains.

Skipping my advil dose that night, I wanted to see if I woke up with more pain than usual.

When I got up, I felt a little bit of aches and pain, but nowhere NEAR what I normally do.

I didn’t skip my morning advil dose, but I could tell that my aches were significantly reduced from what they normally are.

Do think it’s the best joint relief supplement out there?

The jury is still out.

I think I’m going to take the remainder of the bottle and come back here to update my Arthrozene review in another 2 weeks.

Update 8/30!

Sorry about the lateness!  I meant to update this review a few weeks back, but got tied up with other stuff.

So anyway, I continued taking the Arthrozene until I finished out the bottle, and I have to admit it seemed to start wearing off.

It wasn’t the kind of “wearing off” that happened overnight.

It just gradually seemed to lose it’s potency over time.

By the end of the month, if I had to rate it on a 1 – 10 scale (1 being the worst, 10 being the best), I would rate Arthrozene as follows:

Week 1: 6

Week 2: 9

Week 3:  8

Week 4: 6

It’s almost like I was back where I started.  I needed to start taking my twice a day advil dose, as the Arthrozene just wasn’t cutting it any longer.

As far as why the effects of Arthrozene seemed to taper off, I have no idea what could have caused that.

The only thing I can think of is that my body may have built up a sort-or “immunity” to the ingredients.

Tolerance can set in with just about any supplement that is taken over a long period of time, and while it may not always happen, I can’t blame Arthrozene for that.

This has happened to me in the past, but it’s actually VERY rare.

Nonetheless, if you read many of the reviews below, you’ll see that the vast majority of people writing in their Arthrozene reviews are seeing good (and stable) results.

8.  Where to buy

Arthrozene is only available on their official website

The pricing breaks down as follows:

  • 1 bottle:  $49.95
  • 3 bottles:  $44.95 per bottle
  • 6 bottles:  $39.95 per bottle

They do offer a money back guarantee, which is good for 90 days from the date you originally ordered.

arthrozene money back guarantee

At this point, you won’t be able to find Arthrozene in stores like Walmart, Walgreens, CVS, or GNC, but I will update this review when it becomes available.

9.  Conclusion

After finally having tested Arthrozene, I’m still a bit baffled.

As you saw in my personal results, it seemed to work great for the first 2 – 3 weeks.

After that, the effects seemed to almost completely wear off.

With that said, since I wrote my original review we’ve had 15 others leave a review as well.

Literally only 2 of them have left a 1 star rating for it, and the other 13 have rated Arthrozene 4 stars or above. (Click Here to see those reviews)

Based on that alone, I’m upping my original 3 star rating to a 4 star.

Arthrozene does seem to work, and if you’ve been suffering from chronic arthritic pain I would recommend giving it a shot!

If you’re interested, you might want to check out a supplement called Instaflex Advanced.

It’s a bit more expensive that Arthrozene, but in my personal experience was the best joint relief supplement I’ve EVER tested.

And I’ve tested dozens.

You can read more in my full review here.

Have You Used Arthrozene?  Help Us and Others Thinking About Trying This Product Out By Leaving Your Review Below!

Additional References

Have You Used Arthrozene? Click Here To Leave A Review!

Ask A Question

User Questions and Answers

How do I take Arthrozene? -Linda

According to the bottle: "For best results, take one (1) capsule, once per day, with a glass of water on an empty stomach."- Rob

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131 out of 133 people found this question helpful.

Can this be taken in conjunction with otc pain killer until it begins to work -Debra

Yes.- Rob

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95 out of 100 people found this question helpful.

Does Arthrozene work for knee pain? -Mike

The manufacturer (Fisico Inc.) doesn't make any specific claims that it will help with knee pain.  With that said, if you're knee pain is caused specifically by your joints, it should help.- Rob

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85 out of 89 people found this question helpful.

What are the side effects of taking Arthrozene? -Julia

In general, the product is free of side effects.  With that said, its always possible to experience adverse effects with ANY supplement, including Arthrozene.  It's best to check with your doctor first before taking it, as some of the ingredients may interact with certain medications or medical conditions.- Rob

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76 out of 79 people found this question helpful.

What is the active ingredient in Arthrozene? -Jeremy

It doesn't look like there is any one specific ingredient that is the active ingredient.  Rather, they use 3 key ingredients that synergize with one another.  They are ApresFlex Boswellia Serrata Extract, Mobilee Naturak Chicken Comb extract, and B-2Cool Native Collagen type II. I have details on how they work in the Arthrozene review above.- Rob

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61 out of 63 people found this question helpful.

Author: Rob Miller

Supplement Critique

Rob Miller founded over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.

Medical Reviewer: Helen Okoye, MD

Dr Okoye

Dr. Helen Okoye is an American Public Health Physician, Health Care Executive, Researcher, Entrepreneur with a Doctor of Medicine Degree (MD), an MBA in Healthcare Management, and a Masters in Epidemiology/Public Health). Her specific responsibilities for Supplement Critique including reviewing previously published articles for accuracy and relevancy. Her expert opinion was featured on NBC News for the President’s physical exam. Learn more about Dr. Okoye here. Follow here on Twitter and Instagram.

67 comments on “Arthrozene Review”

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  1. I have just started taking arthrozen4 after hearing your presentation and ordering a six monthly supply. No results but will keep you posted.

  2. I have been taking Instaflex advanced for about a year and it seems to work, but still have knee and joint pain. I ordered Arthrozene and I am going to try it.

    Should I stop the Instaflex or do both? I may stop the Instaflex for a month and see what happens.

    I really hope the Arlthrozene will help. I will do a review in a month.

    1. Hey Walter,
      Sorry for the late reply. I would stop taking the Instaflex once you start taking the Arthrozene.

      They share similar ingredients, and you’ll just be taking to high of a dose.
  3. Hi Rob, i was looking at Arthrozene for mum who is 69, as she has arthritis and osteoporosis but she’s a vegetarian and does not even take any eggs, fish or gelatine. Would this product contain such ingredients? if so, do you know any other supplements that will help her to reduce joint pains?

    1. Hey Jenny,
      Well, Arthrozene does contain chicken comb extract, so I don’t believe it’s vegan friendly. I would recommend Instaflex Advanced, but that’s not vegan friendly either because the capsules are gelatin.

      Unfortunately I haven’t done a ton of research on joint supplements, so I’m not aware of any effective ones that are 100% vegan friendly. Sorry!
  4. Thanks for this information. My order of Arthrozene will arrive on Nov. 9th and I’ll start taking it that day.

    Used the original Instaflex and felt pain relief in 3 days. Switched to Ostobioflex a few years that it with some positive effects.

    Now the new Instaflex it contains Tumeric which caused me to break out so I stopped using it. I was a big tennis player for years on a hard surface and with all the lateral movement developed pain in my left knee only.

    Now going down stairs/slopes is painful. Have been unable to play tennis/run for about 8 years.

    Walking now is some pain but recover after a 5-10 min. rest.
    Hope Arthrozene will take some of the pain off.

    1. Hey Tony,
      There’s a 50 / 50 chance it can work for that. I say that because nearly 50% of those who left a review said Arthrozene works for bone on bone pain, and the other 50% said it doesn’t.

      There really is no way to tell for sure without trying it out yourself.
    1. Hey Dorothy,
      Our pharmacist examined the Arthrozene formula and found no known drug interactions. With that said, it’s best to check with your doctor to be completely sure.

  5. I had a bilateral knee surgery on July 19, 2018. A full replacement on my right knee and a partiall one on my left. This coming week, Sept. 17th is my 9th week of recovery.

    I experienced no chronic pain on my left knee but has constant pain on my right knee when I walk, always in the same area. Do you think it’s safe to try either arthrozene or instraflex advanced?

    Or should I give myself more time to heal? Appreciate your recommendations.
    Mahalo, Sherm

    1. Hey Sherman,
      We had our pharmacist go over the formula, and he didn’t find any drug-drug disease state interactions. Did your doctor give you an expected time-frame as to when you’ll be fully healed?

      It might be a good idea to just wait it out for now.
    1. Hi Kathleen,
      We had out pharmacist go over the ingredients profile for Arthrozene, and as far as he can tell it does not have any known drug or disease state interactions. With that said, check with your doctor to be sure.

  6. Regarding pills that are hard to swallow, I have experienced that and notice that drinking water before swallowing the pill, then again with the pill, and more water afterward works to prevent the feeling that it got stuck partway down. Arthrozene is said to be taken on an empty stomach, like when getting up in the pre-dawn hours, after which I go back to bed.

    A normal routine for lots of people anyway. No applesauce, I would guess, as it’s food.

    1. I’m not surprised, it isn’t proven to actually do anything for you. Arthritis doesn’t heal and neither does cartilage.

      Taking arthozene is no more useful than eating a gummy bear every morning, except that it’s a lot more expensive.
  7. Are you recommending Arthrozene over Instaflex Advanced??? I too have had a knee replacement….still bothers me after a few years….the other knee is bone on bone…. shoulder repair with clavical removal….trying to strengthen….have joint pain in other areas….I am 65 & doing a boot camp class 4 x week. ect. I too cannot tolerate taking a bunch of pain stuff because its ruined my stomach….I do not want to give up!!!

    1. Hey Pam,
      Personally speaking, I think Instaflex Advanced is better. Ever since I wrote my original review of it here, I’ve been taking it on and off for about the last 2 years and it’s REALLY helped with minor aches and pains from my joints.

      It seems like to me that when it comes to these joint pain supplements, it’s really hit or miss. Some people get great results with Arthrozene and no results from Instaflex Advanced, and vice versa!
      1. Thx for your reply! So what you’re saying is that it could be luck of the draw And I know how that goes something works for some people sometimes it doesn’t work for others
        1. Yeah more or less. Judging from the amount of reviews I’ve seen for both Arthrozene and Instaflex Advanced, I would say Arthrozene has a leg up here. Out of the 15 reviews we have posted below, only 1 of them rated it 1 star, while everyone else rated it 5 stars.

          I can only tell you that from my personal experience Instaflex Advanced worked better for me.
  8. I have trouble swallowing pills. Can the Arthrozene capsule be opened and the ingredients added to applesauce to take?

  9. I tried Arthrozene for 5 days and had the worst case of diarrhea
    So I discontinued it and would like to return it to you
  10. Thanks for all this great information! I am 61 and just diagnosed with mild to moderate arthritis in my right knee.

    I am going to order this.
  11. I suffer from extreme osteoarthritis of the right knee but the left knee is reasonably healthy. Is it enough to try at least a bottle?

  12. Seems like a lot of money to me, to take such a chance on this product. Price is not friendly to those living on a fixed income.

    1. YOU are right! I really would love to try it but we are not able to pay at one time that great amount.

    1. Hey Joanie,
      I think it may help with mild pain symptoms, but I’d highly doubt that it can alleviate moderate to severe pain. If you’re looking for something to help with moderate / severe pain relief, you may want to check out a substance called Kratom.

      It’s basically an herbal tea that can help with pain dramatically. Check out a vendor called Top Extracts, they make a very high quality product at reasonable prices. Here’s my review:
  13. Been taking arthrozene for about six weeks now – I’ve got bone on bone arthritis in both knees – I could not believe it when my doctor said from my mri that I should be in a lot of pain but I’m not – I feel it has been the arthrozene that has helped – definitely worth a try for anyone!!
    1. I’ve got bone on bone both knees. Started taking this 2months ago.

      Just started seeing a difference. My friend said you’re not using a cane.

      So I’m giving it 1 more month.
  14. I see that there are 30 pills per bottle. My question is, ” Is this a 30 day bottle, like 1 per day?

    How many pills do you take per day is what I’m asking. And do you have larger bottles?”

    1. Yeah it’s one pill per day. As far as I’m aware, Arthrozene does not offer larger bottles.

      However, they do provide discounts for larger orders, so that would be the way to go.
  15. I know this is about Anthrozene, but then there’s an ad for Instaflex. Which is better?
    I’m 68 and in that past 3 years I’ve started getting knock- kneed.

    Legs turning in. What’s up with that?

    And yes, very painful knees even before that happened. I take 1/2 tsp of powdered Tumeric in the mornings and that helps with inflammation a LOT!!!

    Would recommend to everyone. I take it in warm water with honey and 2 tsp organic apple cider vinegar.

    It’s my morning “cup of joe”. 🙂
    1. Hey Janet,
      Sorry for the late reply, your comment slipped through the cracks. Personally speaking, I think Instaflex is more potent (specifically Instaflex Advanced, read my review here)

      I’ve taken both of them, and it just seems to last much longer and deal with the pain more effectively.
  16. I just finished the Arthrozene presentation and the price for 1 bottle is $49LEANdot95. Your site showed a cost of $39.95 so is yours an old price or what?
    1. Hey Dave,

      Looks like you’re right. They must have changed the price.

      Thanks for the heads up. I just updated the review.

    1. Hey Marlise,
      Good question, and to be honest I don’t really have a clear cut answer for you there. I would think it could help with that, but the only way to be sure would be for someone with that exact problem to test it out.

    1. Hey Zeenat,
      It probably depends on the source of your back pain. If it has anything to do with joints, it may help.

      But if it’s a musculoskeletal issue, I doubt Arthrozene would help. Can you describe the source?

      I might be able to help.
  17. I take a prescription narcotic for failed back surgery, but my knees are hurting bad even with the pain meds. Will this be worth trying or not in my case

    1. Hey Gene,
      I highly doubt Arthrozene will be anywhere comparable to that of prescription narcotics, but it may be worth a shot. You might want to check out a substance called Kratom. It’s an herbal tea that is VERY powerful at helping with chronic pain, and is freely available over the counter.

      Check out Top Extracts, it’s my personal favorite and I’ve been ordering from them for close to a year now. Here’s my review:
  18. I just went through the presentation and plan on ordering. I tore my meniscus June 2017 and was diagnosed with osteoarthritis as well.

    Told too young for surgery, I ‘m a very young 61, WAS super active playing tennis, racquetball, pickleball, skiing. It was devastating being immobile for almost 6 months, 3 of them being in a full leg brace, 3/4 and eventually one that allowed me to move.

    I saw a sports orthopedic Dr. and he gave me a sports brace in December 2017 which held my kneecap stationary so when I started slowly playing racquet sports again I didn’t have the sharp pain of bone on bone. Two month ago I ordered an infrared 830 light from the UK. (redlightman) Was skeptical but amazingly happy with results.

    I take all the crazy supplements, fish oil, glucosamine, turmeric daily and advil before engaging in activities. The long presentation was correct in that the more I use my knee the better it is.

    I want to get back to 5-6X a week instead of my 1-2x if I’m lucky so going to give Arthozone a try.
    I plan on cutting out other supplements except Tumeric so I will happily report back on it’s effectiveness.

    Unfortunately, skiing is currently out (lousy snow this season anyway). I will be more than thrilled if I can reintroduce that sport into my schedule.

    Soon 🙂 Diane
  19. I ordered this product based on its presentation. Having no anterior cruciates in both knees and of course arthritis as result of sports a solution short of knee replacements is welcome. 3 days in have have already experienced some

    Wait and see that it’s not psycho somatic relief.
    1. Hey JH,

      Check out our review above. If you decide you want to order some, you can do so at their official website,

  20. Chicken biproducts are vital ingredients in this supplement…is this safe and organic/non-steroidal chicken product?
    I am very skeptical about ingesting chicken parts!

    1. Hey Kate,

      According to their website, it’s been clinically tested and and shown to be safe and effective.
  21. Week 3……no change in my bilateral knee pain/stiffness from osteoarthritis. Not giving up yet.

  22. Day 5 still having pain but the swelling is going down . My knee problems are extensive so I’ll keep you posted to what happens.

  23. I to have knee problems and am waiting to see the results of this pill. I ordered it and got it in a timely manner.

    Now let see what happens. I’m on day 3

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