Zyplex Review

By: Rob Miller
Fact Checked On: 10-15-2018

Warning:Some of this content is not suitable for work, viewer discretion is advised!

I’ve been testing and reviewing male enhancement supplements for close to 7 years now, and one thing never ceases to amaze me…

The sheer amount of pills that tell you that you’ll get a bigger penis from taking their product.

Never mind the fact that the only legit way to increase size is via surgery, there’s certainly no shortage of supplements claiming to increase your size.

So when I came across this ad for Zyplex on an adult film site, I almost chuckled a bit.

zyplex ad

What do you want to know about Zyplex?

What is it?
How does it work?
Are there any side effects?
Will Zyplex make me bigger?
Does it really work?
The truth about Zyplex

What is Zyplex?

That depends on who you ask and what site you’re getting your info from.

For example, the original ad I came across featuring Zyplex touted it as a penis enlargement pill.

does zyplex increase penis size

According to that same site, Zyplex comes highly recommended by a urologist who goes by the name of “Dr. Mason Moore”.

They don’t exactly quote him recommending the product, but they do post a picture of him.

dr mason moore zyplex

I ran a google image search of this guy, and it turns out his image is used on several sites.

This includes this site, which is in German but calls him by a completely different name, and lists a completely different product called “Giant in a Bottle”.

giant in a bottle

But then when you visit their official website, they make no mention of size gains.

Really the only things they do mention are:

  • Increased erection quality
  • Longer stamina
  • Stronger performance

So is Zyplex an enlargement pill or just a sex pill?

How Does Zyplex Work?

According to the official site, Zyplex is more or less a testosterone boosting supplement.

I mean, it says so right on the front of the packaging.

zyplex review

It helps to improve your sexual function and control by 2 mechanisms:

  1. An increase in free testosterone
  2. Nitric oxide production to the penis

How does it do all of this?

Through the all natural, proprietary blend of ingredients of course.

Those ingredients include:

  • Zinc
  • Korean Ginseng
  • Tribulus Terrestris
  • Nettle extract
  • Fenugreek
  • Bioperine
  • Eleuthero

I’ve written pretty extensively about these ingredients, so I’ll only touch on them briefly here.

How does Zinc increase testosterone?

Zinc is one of the most common elements in may of the foods we eat, and is directly responsible at helping to increase testosterone levels.

HOWEVER, taking a supplement that contains zinc is only beneficial if you have an existing zinc deficiency.

If you’re already getting enough Zinc in your diet, taking more won’t do much.

How does Tribulus Terrestris increase testosterone?

Another one of the primary ingredients in Zyplex includes Tribulus Terrestris.

I’ve probably taken dozens of supplements containing Tribulus Terrestris over the years, including Nugenix, Viril X, and Alpha King.

Some of them have worked well, while others haven’t done much.

There’s been a total of 28 studies done of Tribulus Terrestris and it’s effects on testosterone levels, and the jury is still mixed.

For example, some studies conducted in castrated rats showed increased sexual activity.

However, in countless human studies (like this one, this one, and this one), the use of Tribulus Terrestris showed literally NO impact on testosterone levels.

Frequently Asked Questions

Are there any side effects with Zyplex?

If you look at their official website, they make it clear that you will not experience ANY side effects with taking Zyplex.

is zyplex safe

Of course, this is total B.S.

Literally any supplement like this has the potential to cause side effects.

This will of course depend on your own body chemistry and how you react to certain ingredients.

Some of the more common side effects you may experience with Zyplex include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Metallic taste
  • Stomach damage
  • Cramping
  • Insomnia
  • Constipation

It’s always a good idea to check with your doctor before consuming any supplements.

Can I take Zyplex if I have high blood pressure?

  • Nettle extract, found in Zyplex, may lower blood pressure.

    Use caution if you are taking medications to lower your blood pressure. (Source)

Can I take Zyplex if I have LOW blood pressure?

  • Nettle extract, found in Zyplex, may lower blood pressure.

    Use caution if you have low blood pressure.

Can I take Zyplex if I have diabetes?

  • Some of the ingredients may alter blood sugar and alter the effects of insulin.

    When adding a new supplement that may alter blood sugar, it is best to monitor your blood sugar daily for the first week.

    If you experience hypoglycemia, stop the supplement and speak with your doctor about possibly altering your regimen.

Are allergic reactions possible with Zyplex?

  • You should avoid Zyplex if you have an allergy to plants in the Fabaceae family: soybeans, peanuts, and green peas.

Can I take Zyplex with alcohol?

  • Alcohol can cause sleepiness and drowsiness.

    Siberian ginseng found in Zyplex might also cause sleepiness and drowsiness.

    Taking large amounts of Siberian ginseng along with alcohol might cause too much sleepiness.

Can I take Zyplex with Viagra / Cialis?

  • Some of the ingredients may lower blood pressure.

    Use caution as this may cause an unsafe drop in blood pressure.

Can I take if I am taking anti-depressants?

  • It is best to use caution taking supplements, especially those with stimulants (panax ginseng) with any mental disorder.

    Do not take this supplement if you are taking MAOI’s for depression. (See below). Source

Can I take if I have a bleeding disorder?

  • It is best to avoid this supplement if you have a bleeding disorder or taking blood thinners.

    A few of the ingredients in this product may alter your body’s clotting ability.

    If you do choose to use this supplement, monitor for signs and symptoms in increased bleeding including bruising and bleeding gums.

Can I take with caffeine or other stimulants?

  • Panax ginseng found in Zyplex might also speed up the nervous system.

    Taking Panax ginseng along with caffeine might cause serious problems including increased heart rate and high blood pressure.

    Avoid taking caffeine along with Zyplex.

Are there any others medical reasons why I shouldn’t take Zyplex?

Do not take Zyplex if you have:

  • Bleeding Disorders
  • Heart Conditions
  • Diabetes
  • Kidney Problems
  • Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions
  • Insomnia
  • Organ transplant
  • High blood pressure
  • Mental conditions such as mania or schizophrenia

You should stop taking this supplement within two weeks of any surgery.

Possible Drug Interactions

Moderate Interactions:

  • Antibiotics
    • Quinolones
      • ciprofloxacin (Cipro)
      • enoxacin (Penetrex)
      • norfloxacin (Chibroxin, Noroxin)
      • sparfloxacin (Zagam)
      • trovafloxacin (Trovan)
      • grepafloxacin (Raxar)
    • Tetracyclines
      • demeclocycline (Declomycin)
      • minocycline (Minocin)
      • tetracycline (Achromycin)
    • Stimulants
      • diethylpropion (Tenuate)
      • epinephrine
      • phentermine (Ionamin)
      • pseudoephedrine (Sudafed)
      • and many others.
    • Auto-Immune Medications (immunosuppressants for transplant, rheumatoid arthritis, psoriasis, etc.)
      • azathioprine (Imuran)
      • cyclosporine (Neoral, Sandimmune)
      • mycophenolate (CellCept)
      • tacrolimus (Prograf)
      • sirolimus (Rapamune)
      • prednisone (Deltasone, Orasone)
      • corticosteroids (prednisone, etc)
      • and others
    • MAOI’s
      • phenelzine (Nardil)
      • tranylcypromine (Parnate)
      • and others
    • Blood Thinners
      • Aspirin
      • clopidogrel (Plavix)
      • diclofenac (Voltaren, Cataflam, others)
      • ibuprofen (Advil, Motrin, others)
      • naproxen (Anaprox, Naprosyn, others)
      • dalteparin (Fragmin)
      • enoxaparin (Lovenox)
      • heparin
      • warfarin (Coumadin)
      • and others.
    • Sedatives
      • clonazepam (Klonopin)
      • lorazepam (Ativan)
      • phenobarbital (Donnatal)
      • zolpidem (Ambien)
      • and others.
    • Antidiabetic medications
      • glimepiride (Amaryl)
      • glyburide (DiaBeta, Glynase PresTab, Micronase)
      • insulin
      • pioglitazone (Actos)
      • rosiglitazone (Avandia)
      • chlorpropamide (Diabinese)
      • glipizide (Glucotrol)
      • tolbutamide (Orinase)
      • and others
    • Medications metabolized by the liver:
      • Liver Enzyme 2C9
        • amitriptyline (Elavil)
        • diazepam (Valium),
        • zileuton (Zyflo)
        • celecoxib (Celebrex)
        • diclofenac (Voltaren)
        • fluvastatin (Lescol)
        • glipizide (Glucotrol)
        • ibuprofen (Advil, Motrin)
        • irbesartan (Avapro)
        • losartan (Cozaar)
        • phenytoin (Dilantin)
        • piroxicam (Feldene)
        • tamoxifen (Nolvadex)
        • tolbutamide (Tolinase)
        • torsemide (Demadex)
        • warfarin (Coumadin), and others.
      • Liver Enzyme 1A2
        • amitriptyline (Elavil)
        • haloperidol (Haldol)
        • ondansetron (Zofran)
        • propranolol (Inderal)
        • theophylline (Theo-Dur, others)
        • verapamil (Calan, Isoptin, others)
        • and others
      • Liver Enzyme 3A4
        • lovastatin (Mevacor)
        • clarithromycin (Biaxin)
        • cyclosporine (Neoral, Sandimmune)
        • diltiazem (Cardizem)
        • estrogens
        • indinavir (Crixivan)
        • triazolam (Halcion), and many others.
      • Liver Enzyme 2D6
        • amitriptyline (Elavil)
        • clozapine (Clozaril)
        • codeine
        • desipramine (Norpramin)
        • donepezil (Aricept),
        • fentanyl (Duragesic)
        • flecainide (Tambocor)
        • fluoxetine (Prozac)
        • meperidine (Demerol)
        • methadone (Dolophine)
        • metoprolol (Lopressor, Toprol XL)
        • olanzapine (Zyprexa),
        • ondansetron (Zofran)
        • tramadol (Ultram)
        • trazodone (Desyrel), and others.
      • P-glycoprotein Substrates
        • diltiazem (Cardizem)
        • verapamil (Calan, Isoptin, Verelan)
        • digoxin (Lanoxin)
        • cyclosporine (Neoral, Sandimmune)
        • saquinavir (Invirase)
        • amprenavir (Agenerase)
        • nelfinavir (Viracept)
        • loperamide (Imodium)
        • quinidine,
        • paclitaxel (Taxol)
        • vincristine, etoposide (VP16, VePesid)
        • cimetidine (Tagamet)
        • ranitidine (Zantac)
        • fexofenadine (Allegra)
        • ketoconazole (Nizoral)
        • itraconazole (Sporanox)
      • Antihypertensives
        • Thiazides
          • chlorothiazide (Diuril)
          • hydrochlorothiazide (HydroDIURIL, Esidrix)
          • indapamide (Lozol
          • metolazone (Zaroxolyn)
          • chlorthalidone (Hygroton)
        • Calcium Channel Blockers
          • nifedipine (Adalat, Procardia)
          • verapamil (Calan, Isoptin, Verelan)
          • diltiazem (Cardizem)
          • isradipine (DynaCirc)
          • felodipine (Plendil)
          • amlodipine (Norvasc)
          • and others.
        • Potassium Sparing Diuretics
          • amiloride (Midamor)
          • spironolactone (Aldactone)
          • and triamterene (Dyrenium)
        • Other
          • Digoxin
          • Lithium
          • Propranolol
          • Rifampin
          • Theophylline
          • Furosemide (Lasix)
          • Cisplatin (Platinol-AQ)
          • Penicillamine
          • Phenytoin (Dilantin)

Is Zyplex FDA approved?

According to the official website, Zyplex is a male enhancement supplement that is so powerful, you once needed a prescription to get it.

is zyplex a drug

So, from that you would infer that at some point it was a drug, right?

Well, I did some research on the FDA’s Drug establishments registration site, which is where you can find legally registered drugs.

zyplex fdaOf course, I found no mention of Zyplex whatsoever.

no records for zyplex

A search on the regular FDA site turned up nothing either.

fda search

I even searched Drugs.com to see if there was any info on it being a drug, and I see no evidence supporting that claim.

https://www.supplementcritique.com/wp content/uploads/2018/05/drugs dot com

What do Zyplex Reviews have to say?

If you’re looking for credible testimonials, I’m afraid you won’t find any.

I just spent the last 30 minutes pouring over dozens of websites, and absolutely no one has talked about it.

Sure, there are several sites that “say” they have “reviewed” it.

zyplex reviews

However, if you visit these sites about the only thing you’ll find is general info about the Zyplex pills.

In fact, the only credible review we found was on the website Highya.

A visitor to that site left a comment that really laid in to the fact that they are scamming people with their free trial (more on this below).

Unfortunately, he didn’t make any mention as to where or not Zyplex actually works, so we’re left in the dark.

The REAL Truth About Zyplex

So when you go to pick up your “free trial” of Zyplex, you’re led to a page that asks you to put in your credit card info.

“Why do they need my credit card info?”, you may ask?

Well, it’s to pay for the shipping, right?


According to them, shipping is only $4.95, and you should receive your free 30 day supply in just a few days.

What you likely missed because it’s buried at the bottom of the page in extremely fine print is the following:

By submitting, you connect to having read and agreed to out Terms and Conditions and after your 14 day trial period has expired, being enrolled in our membership program for $89.95 plus shipping per month.You can cancel anytime by calling (877) 375-2615.

So basically what this means is, if you don’t call to cancel your trial within 14 days of ordering, they’re going to charge your credit card almost $90.

I’ve seen this countless times, and I’m actually seeing a lot of sites that are literally exact replicas of the Zyplex site.

For example, here’s a snapshot of the Zyplex website.

zyplex website snapshot

Now, take a look at the website for ERX Pro (another male enhancement pill):

erx pro website snapshot

And then there’s the Anamax website.

https://www.supplementcritique.com/wp content/uploads/2018/05/anamax

You can also check out the Testo max website, here’s a snapshot below:

testomax website snapshot

I even wrote a review of a product that had an identical site like this, called VRDHIGGRA.

vrdhhigra website

Ok, so it’s not exactly the same, but are you beginning to see a pattern here??

Be straight with me Rob, what’s going on here?

The B.S works like this.

  1. They (and by they I mean some company located overseas) develop a product called TRT Pro (or whatever you want to call it).
  2. They slap a fancy label on it, and create a website like the one you see above.
  3. They start buying up ads on major porn sites like Xvideos, Porn Hub, and XNXX.
  4. All of these ads have a common theme….they all tell you they will give you increased penis size.
  5. They sucker 1,000’s of guys into thinking they will get a bigger penis from taking this supplement.
  6. They promise a “free trial” which to many sounds like “free sample”. As you can see, this is not the case.
  7. Once they’ve scammed enough guys, they go back to the drawing board and come up with a completely different sounding product and repeat the process.

I can’t tell you how many guys have been scammed by free trials like this.

In fact, it’s so prevalent that I actually wrote a really good blog post on it, detailing exactly how it goes down.


Don’t waste your time with Zyplex. Despite hours of research on my part, there’s no credible info on:

  • How it works
  • Customer testimonials
  • If the ingredients are dosed at the right ratios

Couple that with the fact that the only way to buy it is through their free trial program, and it’s clear to me that these pills are a scam.

This is a fly-by-night company that will stop at nothing to run up a HUGE amount of charges on your credit card without you even knowing it.

If you’re looking for some products that will REALLY give you an increase in size, then check out this post.

It details tried and true methods at helping to gain some serious size, and I’ve personally used these products with GREAT results.

If you’re seriously looking to gain size, then I would seriously recommend you do NOT use Zyplex.

Have You Used Zyplex? Leave Your Review Below!

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Author: Rob Miller

Supplement Critique

Rob Miller founded SupplementCritique.com over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.