Zyrexin Review

By: Rob Miller
44 User Reviews
MD Reviewed By: Helen Okoye, MD What's This?
Fact Checked On: 12-10-2019


My Order of Zyrexin
The Label
My Little Experiment
Frequently Asked Questions
Will Zyrexin Make Me Bigger?
Zyrexin Warnings / Drug Interactions
Zyrexin Vs. Zyrexin Ultra
User Reviews

The guinea pig is back at it again, this time I decided to try Zyrexin all natural sexual stimulant.

This particular supplement calls itself the “worlds strongest sexual enhancer”, but does it really work in under one hour?

Many of these pills, like zyrexin, contain harmful side effects and ingredients that would make you think twice about trying it more than once, but that’s not going to stop us.

I ordered this product last month and finally got around to trying it out personally.

Here is my personal zyrexin review, in it’s truest form.

Update! 12-10-2019

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blue chew review
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1. Zyrexin Order

This product, when compared to many others, is actually pretty cheap. I ordered a 30 capsule bottle on February 24, 2011 off of amazon, for the low low price of $29.35.

my order of zyrexin

I usually don’t finish off the bottle, simply because I am too busy trying out other supplements, and this is the case with this one.

male enhancement supplements weve tested
^ Yes….I’ve tested ALL of these personally

It took about a week to get my order, and I got it from a company called Superbalife International LLC, which according to Bloomberg is located in Los Anegels, CA.

If you look at some of the google reviews of this company, you’ll see that they’re not exactly stellar.

superbalife international reviews

In a discreet, plain marked envelope, I stepped away from my mailbox with a bit of confidence, thinking this might be the answer to my sexual dysfunction problems.

2. Zyrexin Label

According to the label, Zyrexin contains yohimbe, which for those of you who don’t know, can actually be quite dangerous.

where yohimbe comes from
^ Yohimbe Bark Tree

Apparently, yohimbe has been used for hundreds of years to treat erectile dysfunction issues, but has run into a couple of problems lately. There have actually been men that have DIED from taking it!

One was in Maricopa County, Arizona:

death from yohimbe consumption 1

And the other happened in Los Angeles County:

death from yohimbe consumption 2

While there were other substances involved, Yohimbe wasn’t completed ruled out as a primary factor.

Not good.

However, since I originally learned of yohimbe, I’ve actually taken several dozen pills that contain it, including:

Just to name a few…While I may have received some side effects, I never died.

I never died from taking yohimbe, so I got that going for me which is niceZyrexin also contains several other well-known ingredients that are found in other sexual enhancers, including:

    • Epimedium extract
    • Xanthoparmelia Scarbosa
    • Ginkgo Exract
    • Velvet bean
    • Butea Superba
    • L-Arginine

The combo of L-Arginine and yohimbe has actually been clinically studied and proven effective for it’s use in ED. [1, 2]

L-Arginine, which is an amino acid, works by causing a process called vasodilation.Vasodilation is actually the process that happens when you take Viagra. [3]

It works by relaxing the muscle tissue surround the blood vessels, which allows for increased blood flow during erections. [4]

how vasodilation works
^ How vasodilation works

Butea Superba, another key ingredient in Zyrexin, works well when combined with L-Arginine as well. [5]

In fact, one study showed that Butea Superba was actually MORE effective than Viagra in the first part of the study. [6]

Zyrexin has potential drug and medical condition interactions.Click Here to readsome frequently asked questions we get regarding this, as well as a full list of prescription drug interactions.Reviewed byDr. Brian Straub, Pharm.D.

3. Zyrexin Review and Results

I popped my first pill in the morning, and started to feel the effects right around lunchtime. For those of you who just joined this blog, note that I only take these pills on a full stomach, and often only take half the dosage so i know what I am getting myself into. So lunchtime rolls around and I decide to run a little experiment with my “oh so gracious” girlfriend, who happily obliges. We decide to get nitty and gritty, and before you know it, I havea hard on.

Now, let me explain the difference of this hard on. I have tried alot of male enhancement products recently.

Some zyrexin reviewof them make me sick, some make me tired, and others gave me a random increase in energy.

But zyrexin actually made me feel very alert.

Not only that, but my stamina was through the roof!

My hard on was probably one of the biggest erections I have ever experienced, which may be the understatement of the century.

Want To REALLY Get Bigger?

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With little time to spare (girlfriends lunch is only 1 hour, “tick tock doc”), we got downright nasty, and it was a great, fun loving experience. We spent a little time afterwards talking about it, and she said she could actually feel my penis throbbing inside of her.

If you’re looking for an effective boner pill, this is it.

Frequently Asked Questions

4. Are there any side effects?

Yes. Because this supplement contains yohimbe, there is definitely the potential for side effects. This includes increased blood pressure and heart rate, dizziness, headaches, nausea / vomiting, and fever like symptoms to name a few. (Source: WebMD)

Your best bet to counter this is to take it on a full stomach and never take it late in the day, as yohimbe can also cause insomnia.

It should be noted though that if you don’t take it on an empty stomach, it will likely produce significantly less results.

5. Stacking Zyrexin With Phenibut

Once thing I’ve found that works REALLY well with supplements that contain high amounts of yohimbe (like Zyrexin) is a substance called Phenibut.

absorb your health phenibut
Phenibut From AbsorbYourHealth.com

Phenibut is an anti anxiety drug (no shit, it’s actually a drug in Russia and other countries), that will COMPLETELY eliminate all feelings of anxiety and jitters that you would otherwise receive from yohimbe.

According to prior research, Phenibut has been shown to have anxiolytic and nootropic effects as well.

I’ve used it countless times, and it works!

If you do decide to stack it with Zyrexin, I would recommend you take about 500 mg first thing in the am on an empty stomach.

Then about 45 – 60 minutes prior to sexual activity, pop 1 or 2 pills of Zyrexin.

I would recommend waiting at LEAST 3 – 4 hours before taking the Zyrexin, because the Phenibut literally takes that long to kick in.

how to take phenibut infographic

Once it does, though, you’ll be thanking me!

Check out the Absorb Your Health brand of Phenibut. I’ve been using it for years at this point, and it’s very high quality and affordable.

Here’s their site – www.AbsorbYourHealth.com

6. Can I buy Zyrexin in stores?

Yes. As a matter of fact, it’s one of the most popular boner pills sold in stores. I checked with all the major retailers like CVS, Walgreens, Walmart, GNC, Target, and Rite Aid, and practically all of them carry Zyrexin.

zyrexin at cvs

The average price for a 10 count bottle is around $18, so it also makes it one of the cheaper supplements available in this category.

7. How do I take Zyrexin?

The instructions on the label say that you should take 1 to 2 tablets one hour prior to sex, and to not exceed 4 capsules per day.

zyrexin dosage

Of course, I always recommend that you start with a low dose (1 capsule) on a full stomach to assess your tolerance.

Side effects tend to be more pronounced when you take things, like Zyrexin, on an empty stomach, so it’s best to start small.

8. Is it available in Canada, Australia, and the UK?

Because it contains yohimbe (which is banned in those countries), unfortunately you cannot buy it there.

9. Does Zyrexin make you bigger?

I’ve had a TON of guys ask me this question over the years, and the simple answer to this is NO.

Zyrexin will NOT increase your size substantially, at least not permanently.

It will, of course, give you the best possible erection.

But there is no pill on EARTH that will give you permanent size gains.

I know this because I’ve personally tested practically ALL of them that claim to do so.

10. Can women use it?

While it seems to primarily help men, Zyrexin does have the potential to increase female sexual arousal.

How so?

Well, according to one source, yohimbe has been used by women as an aphrodisiac in Africa for 100’s of years.

Just like it does in men, yohimbe allows for increased blood flow to those “sensitive spots”, which ultimately allows for increased pleasure and even the ability to achieve an orgasm.

However, the side effects remain the same, so use Zyrexin with caution.

Zyrexin Warnings / Drug Interactions

Zyrexin could potentially interact with certain medications or medical conditions.

Use caution and speak to a doctor before using it.

We’ve hired a pharmacist who has answered many of the most common questions we get.Reviewed byDr. Brian Straub, Pharm.D.

* Click Here for a full list of potential drug interactions.

Warning: Yohimbe (found in this supplement) and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.

Taking high doses can also cause other severe problems, including difficulty breathing, paralysis, very low blood pressure, heart problems, and death.After taking a one-day dose of yohimbine, one person reported an allergic reaction involving fever; chills; listlessness; itchy, scaly skin; progressive kidney failure; and symptoms that looked like the auto-immune disease called lupus.

Can I take Zyrexin if I have high blood pressure?

Ingredients in this supplement may cause a drop in blood pressure, use caution if you are already taking medications to lower your blood pressure.

Can I take Zyrexin if I have LOW blood pressure?

Ingredients in this supplement may cause a drop in blood pressure, use caution.

Can I take Zyrexin if I have diabetes?

Some of the ingredients may lower blood sugar and alter the effects of insulin.

When adding a new supplement that may lower blood sugar, it is best to monitor your blood sugar daily for the first week.

If you experience hypoglycemia, stop the supplement and speak with your doctor about possibly altering your regimen.

Are allergic reactions possible with Zyrexin?

L-arginine, found in this supplement, can cause an allergic response or make swelling in the airways worse.

If you are prone to allergies or asthma and decide to take L-arginine, use it with caution.

Can I take Zyrexin with alcohol?

While it is best to avoid alcohol while taking supplements, there is no evidence that this supplement interacts with alcohol.

Can I take Zyrexin with Viagra / Cialis?

Ingredients in this supplement may lower blood pressure.

Taking in combination with Viagra or Cialis may lower your blood pressure to an unsafe level.

Use caution.

Can I take if I am taking anti-depressants?

It is best to avoid this supplement if you are taking any anti-depressant medications or suffer from any mental illness.

Can I take Zyrexin if I have a bleeding disorder?

It is best to avoid this supplement if you are taking blood thinners.

If you do choose to use this supplement, monitor for signs and symptoms in increased bleeding including bruising and bleeding gums.

Can I take with caffeine or other stimulants?

It is best to avoid stimulants while taking this supplement.

Are there any others medical reasons why I shouldn’t take this supplement?

Do not take this medication if you have:

  • Bleeding Conditions
  • Schizophrenia
  • Prostate Problems
  • PTSD
  • Liver Disease
  • Kidney Disease
  • Chest Pain/Heart Disease
  • Anxiety
  • Depression
  • Diabetes
  • Deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD)
  • Seizures
  • Diseases of the heart and blood vessels
  • Skin cancer
  • Peptic Ulcer Disease
  • Cirrhosis or liver disease
  • Guanidinoacetate methyltransferase deficiency
  • Herpes
  • Recent Heart Attack

You should stop taking this supplement within two weeks of any surgery.

Possible Drug Interactions


  • Mental Health
    • MAOI’s
      • phenelzine (Nardil)
      • tranylcypromine (Parnate)
    • Blood Thinners
      • Aspirin
      • clopidogrel (Plavix)
      • diclofenac (Voltaren, Cataflam, others)
      • ibuprofen (Advil, Motrin, others)
      • naproxen (Anaprox, Naprosyn, others)
      • dalteparin (Fragmin)
      • enoxaparin (Lovenox)
      • heparin
      • warfarin (Coumadin)
      • and others.
    • Other
      • methyldopa (Aldomet)


  • Mental Health
    • Tricyclic Antidepressants
      • amitriptyline (Elavil)
      • imipramine (Tofranil)
      • and others.
    • Phenothiazines
      • chlorpromazine (Thorazine)
      • fluphenazine (Prolixin)
      • trifluoperazine (Stelazine)
      • thioridazine (Mellaril)
      • and others.
    • Antipsychotics
      • chlorpromazine (Thorazine)
      • clozapine (Clozaril)
      • fluphenazine (Prolixin)
      • haloperidol (Haldol)
      • olanzapine (Zyprexa)
      • perphenazine (Trilafon)
      • prochlorperazine (Compazine)
      • quetiapine (Seroquel)
      • risperidone (Risperdal)
      • thioridazine (Mellaril)
      • thiothixene (Navane)
      • and others.
    • Buspirone (BuSpar)
    • Fluoxetine (Prozac)
  • Medications metabolized by the liver:
    • Liver Enzyme 1A2
      • amitriptyline (Elavil)
      • haloperidol (Haldol)
      • ondansetron (Zofran)
      • propranolol (Inderal)
      • theophylline (Theo-Dur, others)
      • verapamil (Calan, Isoptin, others)
      • and others
    • Liver Enzyme 2D6
      • amitriptyline (Elavil)
      • clozapine (Clozaril)
      • codeine
      • desipramine (Norpramin)
      • donepezil (Aricept),
      • fentanyl (Duragesic)
      • flecainide (Tambocor)
      • fluoxetine (Prozac)
      • meperidine (Demerol)
      • methadone (Dolophine)
      • metoprolol (Lopressor, Toprol XL)
      • olanzapine (Zyprexa),
      • ondansetron (Zofran)
      • tramadol (Ultram)
      • trazodone (Desyrel), and others.
    • Liver Enzyme 2C9
      • amitriptyline (Elavil)
      • diazepam (Valium),
      • zileuton (Zyflo)
      • celecoxib (Celebrex)
      • diclofenac (Voltaren)
      • fluvastatin (Lescol)
      • glipizide (Glucotrol)
      • ibuprofen (Advil, Motrin)
      • irbesartan (Avapro)
      • losartan (Cozaar)
      • phenytoin (Dilantin)
      • piroxicam (Feldene)
      • tamoxifen (Nolvadex)
      • tolbutamide (Tolinase)
      • torsemide (Demadex)
      • warfarin (Coumadin), and others
    • Liver Enzyme 2C19
      • omeprazole (Prilosec)
      • lansoprazole (Prevacid)
      • pantoprazole (Protonix)
      • diazepam (Valium)
      • carisoprodol (Soma)
      • nelfinavir (Viracept)
    • Liver Enzyme 3A4
      • lovastatin (Mevacor)
      • clarithromycin (Biaxin)
      • cyclosporine (Neoral, Sandimmune)
      • diltiazem (Cardizem)
      • estrogens
      • indinavir (Crixivan)
      • triazolam (Halcion), and many others.
    • Stimulants
      • diethylpropion (Tenuate)
      • epinephrine
      • phentermine (Ionamin)
      • pseudoephedrine (Sudafed)
      • and many others.
    • Antidiabetic medications
      • glimepiride (Amaryl)
      • glyburide (DiaBeta, Glynase PresTab, Micronase)
      • insulin
      • pioglitazone (Actos)
      • rosiglitazone (Avandia)
      • chlorpropamide (Diabinese)
      • glipizide (Glucotrol)
      • tolbutamide (Orinase)
      • and others
    • Blood Thinners
      • Aspirin
      • clopidogrel (Plavix)
      • diclofenac (Voltaren, Cataflam, others)
      • ibuprofen (Advil, Motrin, others)
      • naproxen (Anaprox, Naprosyn, others)
      • dalteparin (Fragmin)
      • enoxaparin (Lovenox)
      • heparin
      • warfarin (Coumadin)
      • and others.
    • Nitrates
      • nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat)
      • isosorbide (Imdur, Isordil, Sorbitrate)
    • Anti-hypertensives
      • captopril (Capoten)
      • enalapril (Vasotec)
      • losartan (Cozaar)
      • valsartan (Diovan)
      • diltiazem (Cardizem)
      • Amlodipine (Norvasc)
      • hydrochlorothiazide (HydroDiuril)
      • furosemide (Lasix)
    • Seizure Threshold Lowering Drugs
      • anesthesia (propofol, others)
      • antiarrhythmics (mexiletine)
      • antibiotics (amphotericin, penicillin, cephalosporins, imipenem)
      • antidepressants (bupropion, others)
      • antihistamines (cyproheptadine, others)
      • immunosuppressants (cyclosporine)
      • narcotics (fentanyl, others)
      • stimulants (methylphenidate)
      • theophylline
      • and others.
    • Anticonvulsants
      • Phenobarbital
      • primidone (Mysoline)
      • valproic acid (Depakene)
      • gabapentin (Neurontin)
      • carbamazepine (Tegretol)
      • phenytoin (Dilantin)
      • and others.
    • Others
      • Clonidine (Catapres)
      • Guanabenz (Wytensin)
      • Naloxone (Narcan)
      • Alprazolam (Xanax)
      • Efavirenz (Sustiva)
      • Trazodone (Desyrel)
      • sildenafil (Viagra)

11. Zyrexin Vs. Zyrexin Ultra

When I was doing some research I came across a new product that they’ve come out with called Zyrexin Ultra.

Apparently this new formula works 487% better, and because it’s so strong it’s not available in stores.

zyrexin ultraSo what’s the difference between Zyrexin Ultra and the original?

Well according to them it contains the worlds only natural PDE-5 inhibitor.

If you’re not familiar with what a PDE-5 inhibitor is, I’ll give you a brief lesson.

PDE-5 (Phosphodiesterases) inhibitors were discovered and purified in 1980 from of all things a rats lung.

They work by converting intracellular cGMP to the nucleotide GMP.

What does this mean?

Basically what it does is relaxes the smooth muscle tissue surrounding artery walls, allowing for increased blood flow.

Here’s some scientific stuff to blow your mind:

how pde5 inhbitors work

Originally, PDE-5 inhibitors were meant to work in the treatment of coronary heart disease, but during initial clinical trials an interesting side effect was noticed.

Guys were getting GREAT boners…

That’s right, because of the mechanism of action of PDE-5 inhibitors, it seemed that PDE-5 inhibitors were helping with erectile dysfunction issues.

As a result of extensive clinical studies, we now have Viagra, Tadalifil, and Vardenafil, all of which are PDE-5 inhibitors which help with ED.

Now that you have a little bit of a background on what PDE-5 inhibitors are, what natural ingredient in Zyrexin Ultra causes this?

It’s called L-Arginine.

L-Arginine causes a process called vasodilation, which is EXACTLY the same thing that happens when you take a PDE-5 inhibitor.

how vasodilation works
^ How vasodilation works

It’s actually been called “natural viagra” by some, and I can attest to it’s effectiveness.

In fact, one study on the efficacy and safety of the combination of yohimbe and L-Arginine noted HUGE benefits after just 4 weeks.

Other then that, there’s not much else we know about the product. Price wise, a 1 month supply will cost you about $44.95, which is about $20 more than their original formula.

Both the original and Zyrexin Ultra have a 60 day money back guarantee, which you can exercise up to 60 days past the date of purchase.

12. Zyrexin Recommendation

No side effects, great orgasm, hard as a rock, would definitely recommend to anyone.Be careful of the whole yohimbe thing though, it can really be a pain in the butt if you have heart problems, as noted by several Zyrexin reviews. Check with your doctor if your not sure.

But, if you’re looking for a quick fix, I would certainly recommend popping a zyrexin pill.

Have You Used Zyrexin? Leave Your Review Below!

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How People Found This Review:

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User Reviews

Have you used this supplement?

By joel,  May 20, 2013

I cannot recommend Zyrexin. Sure it did help get an erection, but the side effects are not worth it.


You feel all cold and Jittery, like extreme nervousness, as though you drank 27 cups of coffee. Must be the vast dosages of Yohimbe in it.


Anyway, it is not a healthy product for the heart for sure. Any doctor that recommends this product to his patients should be shot, as it is not all natural.


I feel the Yohimbe could be dangerous if taken over the long haul. Not to mention names, but there are so many other pills to take out there to help with erections that are more natural and don't make you feel like you had 47 cups of coffee and make you feel your heart pounding a mile a minute in your chest.


Zyrexin is not good stuff for the body- period. It gives erections but its dangerous.


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96 out of 110 people found this review helpful.

By George,  Jul 29, 2013

Stay away. My dear guys and men, stay away from this product.


Not only you can die because of these chemicals in your system, just because you have taken the product, you will not feel healthy at all. I have tried taking the product two times.


The results are dizziness, nausea, tingling all over, and fever coupled with chills.

Not only will you have forgotten about your sex life, but you will be thinking only about your own survival. You just feel like shit, period!


This poison will give you a lot of problems at the cost of your own money! Stay away!


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76 out of 85 people found this review helpful.

Nope. Nope. Nope.

By Dr. Zoidberg,  Dec 22, 2015

I basically paid money for an uncomfortably high heart rate, and no other effects to speak of. I'd trade the other 11 pills for a pack of gum.


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41 out of 47 people found this review helpful.


By John Andrew,  Feb 26, 2014

I took two pills at two different times and had severe burning pains in my rectum and penis. I threw the rest of the pills in the trash.


That is the problem I had but everybody may not have that problem or any problem at all.

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43 out of 55 people found this review helpful.

By Wayne,  May 17, 2013

I tried Zyrexin yesterday. I started out with 1 pill. and nothing happened.


I took another pill a few hours later, and still, nothing happened. It was a totally worthless product.


I've taken stiff nights and it works really well although gives me a headache, and stuffy nose.

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36 out of 46 people found this review helpful.

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Ask A Question

User Questions and Answers

I'm looking for a male enhancement that works I've narrowed it down to either Extenze extended release or Zyrexin. Which one do you like better? -waylon

They're both good, but my preference is for Extenze Extended Release. I like that it works instantly and in the long run as well.- Rob

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22 out of 23 people found this question helpful.

I had a stroke 3 years ago. I am being treated for high blood pressure which is under control. Is Zyrexin safe for me to take? -Bob

Since you're taking prescription medication, you'll need to consult with your doctor about what supplements might be contraindicated.  - Rob

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14 out of 18 people found this question helpful.

How long does Zyrexin take to work? -Amanda

It should take about 30-45 minutes to start working.- Rob

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8 out of 8 people found this question helpful.

What are the side effects of Zyrexin? -DexterTarleton

Because this supplement contains yohimbe, there is definitely the potential for side effects, and as you can read in some of the feedback on this review, plenty of guys have experienced them. These include increased blood pressure and heart rate, dizziness, headaches, nausea / vomiting, and fever like symptoms to name a few. Your best bet to counter this is to take it on a full stomach and never take it late in the day, as yohimbe can also cause insomnia.- Rob

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7 out of 8 people found this question helpful.

I am 300lb and I took 3 tablets for the 1st time and my face got red feverish and I had a fast heartbeat. I have no known health problems. Would it be safe to take Zyrexin again with a lower dose? -bobby

Try taking one pill with food. That way, if you do get any type of reaction, it'll be much less.- Rob

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10 out of 14 people found this question helpful.

Author: Rob Miller

Supplement Critique

Rob Miller founded SupplementCritique.com over 7 years ago, and has been the chief editor ever since. He has a diploma in Advanced Dietary Supplements Advisor, and worked at GNC for 3 years. He KNOWS supplements, both inside and out. Rob currently resides in Jupiter, FL, with his wife of 4 years.  Learn more about him in his Bio here. Follow him on Twitter , Facebook, LinkedIn, or find him on Google +.

Medical Reviewer: Helen Okoye, MD

Dr Okoye

Dr. Helen Okoye is an American Public Health Physician, Health Care Executive, Researcher, Entrepreneur with a Doctor of Medicine Degree (MD), an MBA in Healthcare Management, and a Masters in Epidemiology/Public Health). Her specific responsibilities for Supplement Critique including reviewing previously published articles for accuracy and relevancy. Her expert opinion was featured on NBC News for the President’s physical exam. Learn more about Dr. Okoye here. Follow here on Twitter and Instagram.